T
Thomas Fischer
Researcher at University of Würzburg
Publications - 17
Citations - 382
Thomas Fischer is an academic researcher from University of Würzburg. The author has contributed to research in topics: Radiation sensitivity & DNA damage. The author has an hindex of 6, co-authored 17 publications receiving 337 citations.
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Oligothiophenes - yet longer - synthesis, characterization, and scanning-tunneling-microscopy images of homologous, isomerically pure oligo(alkylthiophene)s
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Oligothiophene – immer länger? Synthese, Charakterisierung und rastertunnelmikroskopische Abbildung von homologen, isomerenreinen Oligo(alkylthiophenen)
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Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Fabian Braun,Thomas Fischer,Susanne Walz,Christina Schülein-Völk,Ursula Eilers,Carsten P. Ade,Marco A. Calzado,Amir Orian,Hans Michael Maric,Christian Münch,Mathias T. Rosenfeldt,Martin Eilers,Markus E. Diefenbacher +15 more
TL;DR: It is reported that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 levels in SCC by counteracting its proteasome‐mediated degradation.
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Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Oliver Hartmann,Michaela Reissland,Carina R. Maier,Thomas Fischer,Cristian Prieto-Garcia,Cristian Prieto-Garcia,Apoorva Baluapuri,Jessica Denise Schwarz,Werner Schmitz,Martín Garrido-Rodríguez,Nikolett Pahor,Clare C. Davies,Florian Bassermann,Amir Orian,Elmar Wolf,Almut Schulze,Marco A. Calzado,Mathias T. Rosenfeldt,Markus E. Diefenbacher +18 more
TL;DR: In this paper, the authors used CRISPR/Cas9-mediated targeting of Trp53 and KRas in lung cancer patients to develop tumor models with similar morphology, marker expression and transcriptional profiles.
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S-adenosyl-L-methionine counteracts mitotic disturbances and cytostatic effects induced by sodium arsenite in HeLa cells.
TL;DR: The mechanism by which SAM reduces the frequency of aneuploid cells must be related to the modulation of the dynamics and organization of MT, suggesting a role of SAM on chromosome segregation, which should be further investigated in primary cells.