C
Cuong J. Tran
Researcher at University of California, Berkeley
Publications - 5
Citations - 44
Cuong J. Tran is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Rickettsiosis & Rickettsia. The author has an hindex of 2, co-authored 5 publications receiving 13 citations.
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Journal ArticleDOI
Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy.
TL;DR: This article showed that protein-lysine methyltransferases (PKMTs) are essential determinants of rickettsial pathogenesis that shields bacterial proteins from ubiquitylation to evade autophagic targeting.
Journal ArticleDOI
Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis.
Thomas P. Burke,Patrik Engström,Cuong J. Tran,Ingeborg M. Langohr,Dustin R. Glasner,Diego A. Espinosa,Eva Harris,Matthew D. Welch +7 more
TL;DR: Burke et al. as mentioned in this paper showed that interferon signalling protects laboratory mice against R. parkeri infections. But, their experiments were performed on mice that had or lacked two specific receptors, and they did not show that these receptors were essential for the bacteria to cause skin lesions.
Posted ContentDOI
A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes
Gina M. Borgo,Thomas P. Burke,Cuong J. Tran,Nicholas T. N. Lo,Patrik Engström,Matthew D. Welch +5 more
TL;DR: The role of a patatin-like phospholipase A2 enzyme (Pat1) during host cell infection by characterizing a Rickettsia parkeri mutant with a transposon insertion in the pat1 gene was investigated in this article.
Posted ContentDOI
Rickettsia parkeri Sca2 promotes dissemination in an intradermal infection mouse model
Thomas P. Burke,Cuong J. Tran,Patrik Engström,Dustin R. Glasner,Diego A. Espinosa,Eva Harris,Matthew D. Welch +6 more
TL;DR: This study characterizes a mouse model that mimics aspects of human rickettsial disease and reveals a pathogenic role for the R. parkeri actin-based motility protein Sca2 in dissemination.
Posted ContentDOI
Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis
Thomas P. Burke,Patrik Engström,Cuong J. Tran,Dustin R. Glasner,Diego A. Espinosa,Eva Harris,Matthew D. Welch +6 more
TL;DR: This work reports that intradermal infection of mice deficient for both interferon receptors (Ifnar-/-Ifngr-/-) with R. parkeri causes eschar formation, recapitulating the hallmark clinical feature of human disease, and finds that the actin-based motility protein Sca2 is required for R. Parkeri dissemination from the skin to internal organs and for causing lethal disease.