C
Cynthia N. Perry
Researcher at Texas Tech University Health Sciences Center at El Paso
Publications - 23
Citations - 1158
Cynthia N. Perry is an academic researcher from Texas Tech University Health Sciences Center at El Paso. The author has contributed to research in topics: Autophagy & Mitochondrion. The author has an hindex of 13, co-authored 21 publications receiving 1061 citations. Previous affiliations of Cynthia N. Perry include University of Arizona & San Diego State University.
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Journal ArticleDOI
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
Hua Yuan,Cynthia N. Perry,Chengqun Huang,Eri Iwai-Kanai,Raquel S. Carreira,Christopher C. Glembotski,Roberta A. Gottlieb +6 more
TL;DR: The notion that autophagy is a cytoprotective response to LPS-induced cardiomyocyte injury is supported; additional studies are needed to determine the therapeutic implications.
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Autophagy induced by ischemic preconditioning is essential for cardioprotection.
Chengqun Huang,Smadar Yitzhaki,Cynthia N. Perry,Cynthia N. Perry,Wayne Liu,Zoltán Giricz,Robert M. Mentzer,Robert M. Mentzer,Roberta A. Gottlieb +8 more
TL;DR: Findings establish autophagy as an end-effector in ischemic and pharmacologic preconditioning and assesses three structurally unrelated cardioprotective agents for their ability to induce Autophagy in HL-1 cells.
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Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.
TL;DR: Reducing MURF-2 levels in cardiac myocytes using antisense oligonucleotides perturbed the structure of stable microtubule populations, the intermediate filament proteins desmin and vimentin, and the Sarcomeric M-line region, while other sarcomeric regions and dynamic microtubules remained unaffected.
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
Christian Riehle,Adam R. Wende,Sandra Sena,Karla Maria Pereira Pires,Renata O. Pereira,Yi Zhu,Heiko Bugger,Deborah U. Frank,Jack Bevins,Dong Chen,Cynthia N. Perry,Xiaocheng C. Dong,Steven Valdez,Monika Rech,Xiaoming Sheng,Bart C. Weimer,Roberta A. Gottlieb,Morris F. White,Evan Dale Abel +18 more
TL;DR: It is shown that in addition to prosurvival signaling, insulin action in early life mediates the physiological postnatal suppression of autophagy, thereby linking nutrient sensing to postnatal cardiac development.
Journal ArticleDOI
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.
Chengqun Huang,Wayne Liu,Cynthia N. Perry,Smadar Yitzhaki,Youngil Lee,Hua Yuan,Yayoi Tetsuo Tsukada,Anne Hamacher-Brady,Robert M. Mentzer,Robert M. Mentzer,Roberta A. Gottlieb +10 more
TL;DR: These studies indicate that cardioprotection mediated by SUL involves a PKC-dependent induction of autophagy, and suggest that autophagic may be a fundamental process that enhances the heart's tolerance to ischemia.