D
D.C. Morse
Researcher at Wageningen University and Research Centre
Publications - 9
Citations - 957
D.C. Morse is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Developmental toxicity & Triiodothyronine. The author has an hindex of 8, co-authored 9 publications receiving 936 citations.
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Journal ArticleDOI
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants
Abraham Brouwer,Ulf G. Ahlborg,Martin van den Berg,Linda S. Birnbaum,E. Ruud Boersma,Bart A.T.C. Bosveld,Michael S. Denison,L. Earl Gray,Lars Hagmar,Edel Holene,M Huisman,Sandra W. Jacobson,Joseph L. Jacobson,C. Koopman-Esseboom,Janna G. Koppe,Beverly M. Kulig,D.C. Morse,Gina Muckle,Richard E. Peterson,Pieter J J Sauer,Richard F. Seegal,Annette E. Smits-van Prooije,Bert C.L. Touwen,N. Weisglas-Kuperus,Gerhard Winneke +24 more
TL;DR: The lowest observable adverse effect levels (LOAELs) for developmental neurobehavioral and reproduction endpoints, based on body burden of TCDD-toxic equivalents (TEQs) in animals, are within the range of current background human body burdens.
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Alterations in Rat Brain Thyroid Hormone Status Following Pre- and Postnatal Exposure to Polychlorinated Biphenyls (Aroclor 1254)
TL;DR: The results suggest that the accumulation of hydroxylated PCB metabolites in fetal plasma can reduce fetal plasma T4 levels and accordingly fetal brain T3 levels in late gestational fetuses.
Journal ArticleDOI
Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats
D.C. Morse,D. Groen,M. Veerman,C.J. van Amerongen,H.B.W.M. Koeter,A.E. Smits van Prooije,T.J. Visser,Jan H. Koeman,Abraham Brouwer +8 more
TL;DR: The effects of prenatal oral administration of HCB and/or TCB result in increased peripheral T4 metabolism, which may help explain the mechanism of developmental neurotoxicity induced by polychlorinated biphenyls.
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In vitro metabolism of 3,3',4,4'-tetrachlorobiphenyl in relation to ethoxyresorufin-O-deethylase activity in liver microsomes of some wildlife species and rat.
TL;DR: The mammals and birds were able to metabolize TCB at a rate that correlated with their ethoxyresorufin-O-deethylase (EROD) activity, and the ratio of the different hydroxy metabolites formed varied for the various species.
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Impaired cellular immune response in rats exposed perinatally to Baltic Sea herring oil or 2,3,7,8-TCDD.
Peter S. Ross,Rik L. de Swart,Helen van der Vliet,Linette Willemsen,Arja de Klerk,Geert van Amerongen,Jan Groen,Abraham Brouwer,Ineke Schipholt,D.C. Morse,Henk Van Loveren,Albert D. M. E. Osterhaus,Joseph G. Vos +12 more
TL;DR: The collective results of these studies in rats and seals indicate the immunotoxic potential of environmental mixtures at current levels in the aquatic environment, and suggest that the developing immune system of young mammals may be at particular risk.