R
Rik L. de Swart
Researcher at Erasmus University Rotterdam
Publications - Â 138
Citations - Â 9367
Rik L. de Swart is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Measles virus & Virus. The author has an hindex of 49, co-authored 127 publications receiving 7462 citations. Previous affiliations of Rik L. de Swart include University of Tennessee Health Science Center & World Health Organization.
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Journal ArticleDOI
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome.
Daniela Weiskopf,Katharina S. Schmitz,Matthijs P. Raadsen,Alba Grifoni,Nisreen M.A. Okba,Henrik Endeman,Johannes P. C. van den Akker,Richard Molenkamp,Marion Koopmans,Eric C. M. van Gorp,Bart L. Haagmans,Rik L. de Swart,Alessandro Sette,Alessandro Sette,Rory D. de Vries +14 more
TL;DR: Study of COVID-19 patients who required admission to an intensive care unit and detected SARS-CoV-2-specific CD4+ and CD8+ T cells detected shed light on the potential variations in T-cell responses as a function of disease severity, an issue that is key to understanding the potential role of immunopathology in the disease.
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Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Barry Rockx,Thijs Kuiken,Sander Herfst,Theo M. Bestebroer,Mart M. Lamers,Bas B. Oude Munnink,Dennis de Meulder,Geert van Amerongen,Judith M. A. van den Brand,Nisreen M.A. Okba,Debby Schipper,Peter van Run,Lonneke Leijten,Reina S. Sikkema,Ernst J. Verschoor,Babs E. Verstrepen,Willy M. J. M. Bogers,Jan A.M. Langermans,Jan A.M. Langermans,Christian Drosten,Martje Fentener van Vlissingen,Ron A. M. Fouchier,Rik L. de Swart,Marion Koopmans,Bart L. Haagmans +24 more
TL;DR: Comparisons of three human coronaviruses in cynomolgus macaques show that SARS-CoV-2 causes COVID-19–like disease in macaques and provides a new model to test preventive and therapeutic strategies.
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SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees.
Daryl Geers,Marc C. Shamier,Susanne Bogers,Gerco den Hartog,Lennert Gommers,Nella N Nieuwkoop,Katharina S. Schmitz,Laurine C Rijsbergen,Jolieke A T van Osch,Emma Dijkhuizen,Gaby Smits,Anouskha D. Comvalius,Djenolan van Mourik,Tom G. Caniels,Marit J. van Gils,Rogier W. Sanders,Bas B. Oude Munnink,Richard Molenkamp,Herbert de Jager,Bart L. Haagmans,Rik L. de Swart,Marion Koopmans,Robert S. van Binnendijk,Rory D. de Vries,Corine H. GeurtsvanKessel +24 more
TL;DR: In this article, the authors studied humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.7 and B.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinated health care workers.
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Antigenic and Genetic Variability of Human Metapneumoviruses
Bernadette G. van den Hoogen,Sander Herfst,Leo Sprong,Patricia A. Cane,Eduardo Forleo-Neto,Rik L. de Swart,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +7 more
TL;DR: On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined and each serotype could be divided into two genetic lineages, but these did not reflect major antigenic differences.
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Impairment of Immune Function in Harbor Seals (Phoca vitulina) Feeding on Fish from Polluted Waters
Rik L. de Swart,Peter S. Ross,Lies Vedder,H.H. Timmerman,Siem Heisterkamp,Henk van Loveren,Joseph G. Vos,P.J.H. Reijnders,Albert D. M. E. Osterhaus +8 more
TL;DR: It is found that natural killer-cell activity and mitogen-induced proliferative T -cell responses from the seals feeding on herring from the Baltic Sea were significantly lower, and higher levels of circulating polymorphonuclear granulocytes in these animals may indicate an increase in the occurrence of bacterial infections.