D
D. Dexter
Researcher at University of Cambridge
Publications - 16
Citations - 7205
D. Dexter is an academic researcher from University of Cambridge. The author has contributed to research in topics: Substantia nigra & Parkinson's disease. The author has an hindex of 12, co-authored 13 publications receiving 6850 citations. Previous affiliations of D. Dexter include University of London.
Papers
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Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
Journal ArticleDOI
Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
D. Dexter,C.J. Carter,F. R. Wells,F. Javoy-Agid,Yves Agid,Andrew J. Lees,Peter Jenner,C. D. Marsden +7 more
TL;DR: The results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species.
Journal ArticleDOI
Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease
TL;DR: Increased levels of total iron in the substantia nigra may cause the excessive formation of toxic oxygen radicals, leading to dopamine cell death, in Parkinson's disease.
Journal ArticleDOI
Increased nigral iron content in postmortem parkinsonian brain.
Journal ArticleDOI
Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease
Anthony H.V. Schapira,V. M. Mann,JM Cooper,D. Dexter,S. E. Daniel,Peter Jenner,J. B. Clark,C. D. Marsden +7 more
TL;DR: It is shown that complex I deficiency in Parkinson's disease is anatomically specific for the substantia nigra, and is not present in another neurodegenerative disorder involving the substanta nigra.