D
Dagan A. Loisel
Researcher at University of Chicago
Publications - 19
Citations - 1591
Dagan A. Loisel is an academic researcher from University of Chicago. The author has contributed to research in topics: Population & Gene. The author has an hindex of 13, co-authored 19 publications receiving 1456 citations. Previous affiliations of Dagan A. Loisel include Massachusetts Institute of Technology & Saint Michael's College.
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Journal ArticleDOI
Sex-specific genetic architecture of human disease
TL;DR: Genetic studies that ignore sex-specific effects in their design and interpretation could fail to identify a significant proportion of the genes that contribute to risk for complex diseases.
Journal ArticleDOI
Nf1 ; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
Karlyne M. Reilly,Dagan A. Loisel,Roderick T. Bronson,Margaret McLaughlin,Margaret McLaughlin,Tyler Jacks +5 more
TL;DR: This mouse model is the first reported mouse model of astrocytoma initiated by loss of tumour suppressors, rather than overexpression of transgenic oncogenes, and may accurately model human secondary glioblastoma involving TP53 loss.
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Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects
Karlyne M. Reilly,Robert G. Tuskan,Emily S. Christy,Dagan A. Loisel,Jeremy Ledger,Roderick T. Bronson,C. Dahlem Smith,Shirley Tsang,David J. Munroe,Tyler Jacks +9 more
TL;DR: It is demonstrated that epigenetic effects can have a strong effect on whether cancer develops in the context of mutant ras signaling and mutant p53, and that this mouse model of astrocytoma can be used to identify modifier phenotypes with complex inheritance patterns that would be unidentifiable in humans.
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Positive selection on MMP3 regulation has shaped heart disease risk.
Matthew V. Rockman,Matthew W. Hahn,Matthew W. Hahn,Nicole Soranzo,Dagan A. Loisel,David Goldstein,Gregory A. Wray +6 more
TL;DR: Locally elevated mutation rates and strong positive selection on a cis-regulatory variant have shaped contemporary phenotypic variation and public health.
Journal ArticleDOI
Ancient polymorphism and functional variation in the primate MHC-DQA1 5′ cis-regulatory region
Dagan A. Loisel,Matthew V. Rockman,Gregory A. Wray,Jeanne Altmann,Jeanne Altmann,Susan C. Alberts +5 more
TL;DR: The functional differentiation of baboon promoter haplotypes, together with the significant deviations from neutral sequence evolution, suggests a role for balancing selection in the evolution of DQA1 transcriptional regulation in primates.