Dalci José Brondani

TL;DR: Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents and revealed that they are able to promote the growth of some organisms, including Bacillus subtilis.

TL;DR: Lead compounds exhibiting in vitro activity against both the epimastigote and trypomastigotes forms of T. cruzi were identified and in vivo general toxicity analysis was subsequently performed, and novel SAR were documented, including the importance of the thiocarbonyl carbon attached to the thiazolyl ring.

TL;DR: The synthesis of peptidyl-like derivatives containing the 1,3-benzodioxole system is described, suggesting that Safrole acts as a 'cell cycle-nonspecific' inhibitory agent and tyrosine and lysine as the most active among them.

TL;DR: The thiazolidinone ring was employed as a bioisosteric replacement for pteridine/purine ring in order to design a novel class of PTR1 inhibitors and was identified as the most promising lead by thermal shift assays.

TL;DR: A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy and some compounds were found to have significant activity against Gram positive and Gram negative microorganisms.