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Dan C. Freed
Researcher at United States Military Academy
Publications - 5
Citations - 1188
Dan C. Freed is an academic researcher from United States Military Academy. The author has contributed to research in topics: T cell & DNA vaccination. The author has an hindex of 4, co-authored 5 publications receiving 1184 citations. Previous affiliations of Dan C. Freed include Merck & Co..
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Journal ArticleDOI
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF.
Dan H. Barouch,Sampa Santra,Klara Tenner-Racz,Paul Racz,Marcelo J. Kuroda,Joern E. Schmitz,Shawn S. Jackson,Michelle A. Lifton,Dan C. Freed,Helen C. Perry,Mary-Ellen Davies,John W. Shiver,Norman L. Letvin +12 more
TL;DR: It is demonstrated that bicistronic DNA vaccines containing GM-CSF elicit remarkably potent CD4+ T cell responses and suggest that optimal Th cell priming requires the precise temporal and spatial codelivery of Ag and GM- CSF.
Journal ArticleDOI
Cross-Reactivity of Anti–HIV-1 T Cell Immune Responses among the Major HIV-1 Clades in HIV-1–Positive Individuals from 4 Continents
Paul Coplan,Swati B. Gupta,Sheri Dubey,Punnee Pitisuttithum,Alex Nikas,Bernard Mbewe,Efthyia Vardas,Mauro Schechter,Esper G. Kallas,Dan C. Freed,Tong-Ming Fu,Christopher T. Mast,Pilaipan Puthavathana,James Kublin,Kelly B. Collins,John Chisi,Richard Pendame,Scott Thaler,Glenda Gray,James McIntyre,Walter L. Straus,Jon H. Condra,Devan V. Mehrotra,Harry A. Guess,Emilio A. Emini,John W. Shiver +25 more
TL;DR: Cross-clade reactivity of cellular immune responses can be substantial but varies by viral protein, and predominantly focused on viral Gag and Nef proteins.
Journal ArticleDOI
Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon
Swati B. Gupta,Christopher T. Mast,Nathan D. Wolfe,Vlad Novitsky,Sheri Dubey,Esper G. Kallas,Mauro Schechter,Bernard Mbewe,Eftyhia Vardas,Punee Pitisuttithum,Donald S. Burke,Dan C. Freed,Robin Mogg,Paul Coplan,Jon H. Condra,Romnie Long,Kiersten Anderson,Danilo R. Casimiro,John W. Shiver,Walter L. Straus +19 more
TL;DR: Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.