W
Wendy L. Trigona
Researcher at United States Military Academy
Publications - 10
Citations - 3323
Wendy L. Trigona is an academic researcher from United States Military Academy. The author has contributed to research in topics: Antigen & CTL*. The author has an hindex of 9, co-authored 10 publications receiving 3288 citations.
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Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Journal ArticleDOI
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene
Danilo R. Casimiro,Ling Chen,Tong-Ming Fu,Robert K. Evans,Michael J. Caulfield,Mary-Ellen Davies,Aimin Tang,Minchun Chen,Lingyi Huang,Virginia Harris,Daniel C. Freed,Keith A. Wilson,Sheri Dubey,De-Min Zhu,Denise K. Nawrocki,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,William M. Hurni,Zheng Xu,Jeffrey G. Smith,Su Wang,Xu Liu,Liming Guan,Romnie Long,Wendy L. Trigona,Gwendolyn J. Heidecker,Helen C. Perry,Natasha Persaud,Timothy J. Toner,Qin Su,Xiaoping Liang,Rima Youil,Michael Chastain,Andrew J. Bett,David B. Volkin,Emilio A. Emini,John W. Shiver +38 more
TL;DR: Results are suggestive of an immunization strategy for humans that is centered on use of the adenovirus vector and in which existing adenavirus immunity may be overcome by combined immunization with adjuvanted DNA and adenvirus vector boosting.
Journal ArticleDOI
Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
Holden T. Maecker,Holli S Dunn,Maria A. Suni,Elham Khatamzas,Elham Khatamzas,Christine J. Pitcher,Torsten Bunde,Natasha Persaud,Wendy L. Trigona,Tong-Ming Fu,Elizabeth Sinclair,Barry M. Bredt,Joseph M. McCune,Vernon C. Maino,Florian Kern,Louis J. Picker +15 more
TL;DR: Over overlapping 15 amino acid peptide mixes may facilitate the analysis of antigen-specific CD4+ and CD8+ T-cell responses by cytokine flow cytometry, using clinical specimens that include shipped blood or cryopreserved PBMC.
Journal ArticleDOI
Putative Immunodominant Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype
Michael R. Betts,Joseph P. Casazza,Brent A. Patterson,Shar L. Waldrop,Wendy L. Trigona,Tong-Ming Fu,Florian Kern,Louis J. Picker,Richard A. Koup +8 more
TL;DR: Data indicate that an individual's overall CD8+ T-cell response to HIV is not adequately represented by the response to a single epitope and that individual major histocompatibility complex class I alleles do not predict an immunodominant response restricted by that allele.