J
James McIntyre
Researcher at University of Cape Town
Publications - 307
Citations - 16124
James McIntyre is an academic researcher from University of Cape Town. The author has contributed to research in topics: Population & Men who have sex with men. The author has an hindex of 60, co-authored 298 publications receiving 14840 citations. Previous affiliations of James McIntyre include University of the Witwatersrand & Chris Hani Baragwanath Hospital.
Papers
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Journal ArticleDOI
Early Antiretroviral Therapy and Mortality among HIV-Infected Infants
Avy Violari,Mark F. Cotton,Diana M. Gibb,Abdel Babiker,Jan Steyn,Shabir A. Madhi,Patrick Jean-Philippe,James McIntyre +7 more
TL;DR: Early HIV diagnosis and early antiretroviral therapy reduced early infant mortality by 76% and HIV progression by 75%.
Journal ArticleDOI
Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis.
Deborah Donnell,Deborah Donnell,Jared M. Baeten,James Kiarie,James Kiarie,Katherine K. Thomas,Wendy S. Stevens,Craig R. Cohen,James McIntyre,Jairam R. Lingappa,Connie Celum +10 more
TL;DR: In this article, the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners was evaluated in a randomised placebo-controlled trial that enrolled heterosexual African adults who were seropositive for both HIV and herpes simplex virus type 2.
Journal ArticleDOI
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
Connie Celum,Anna Wald,Anna Wald,J.R. Lingappa,Amalia Magaret,Amalia Magaret,Richard S. Wang,Nelly Mugo,Nelly Mugo,Andrew Mujugira,Jared M. Baeten,James I. Mullins,James P. Hughes,Elizabeth A. Bukusi,Elizabeth A. Bukusi,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,James Kiarie,Carey Farquhar,Grace John Stewart,Joseph Makhema,Myron Essex,Edwin Were,Kenneth H. Fife,G de Bruyn,Glenda Gray,James McIntyre,Rachel Manongi,Saidi Kapiga,David Coetzee,Susan Allen,Mubiana Inambao,Kayitesi Kayitenkore,Etienne Karita,William Kanweka,Sinead Delany,Helen Rees,Bellington Vwalika,Wendy S. Stevens,Campbell,Katherine K. Thomas,Robert W. Coombs,Rhoda Ashley Morrow,William L. H. Whittington,M J McElrath,M J McElrath,Linda E Barnes,Renee Ridzon,Lawrence Corey,Lawrence Corey +51 more
TL;DR: Daily acyclovir therapy did not reduce the risk of transmission of HIV-1, despite a reduction in plasma HIV- 1 RNA of 0.25 log(10) copies per milliliter and a 73% reduction in the occurrence of genital ulcers due to HSV-2.
Journal ArticleDOI
Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis.
Jean B. Nachega,Olalekan A. Uthman,Olalekan A. Uthman,Jean Anderson,Karl Peltzer,Karl Peltzer,Sarah Wampold,Mark F. Cotton,Edward J Mills,Yuh-Shan Ho,Jeffrey S. A. Stringer,Jeffrey S. A. Stringer,James McIntyre,Lynne M. Mofenson +13 more
TL;DR: It is indicated that only 73.5% of pregnant women achieved optimal ART adherence, and specific barriers for nonadherence included physical, economic and emotional stresses, depression, alcohol or drug use, and ART dosing frequency or pill burden.
Journal ArticleDOI
A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1.
Dhayendre Moodley,Jagidesa Moodley,Hoosen M. Coovadia,Glenda E. Gray,James McIntyre,Justus Hofmyer,Cheryl Nikodem,David B. Hall,Maria Gigliotti,Patrick A. Robinson,Lynette Boshoff,South African Intrapartum Nevirapine Trial (Saint) Investigators +11 more
TL;DR: In this paper, the efficacy and safety of two inexpensive and easily deliverable antiretroviral (ARV) regimens for the prevention of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) type 1 during labor and delivery HIV-infected pregnant women were screened at 11 maternity health institutions in South Africa and were enrolled in an open-label short course ARV regimen of either nevirapine (Nvp) or multiple-dose zidovudine and lamivudine (Zdv/3TC