D
Danilo R. Casimiro
Researcher at United States Military Academy
Publications - 72
Citations - 6671
Danilo R. Casimiro is an academic researcher from United States Military Academy. The author has contributed to research in topics: Immune system & Vaccination. The author has an hindex of 35, co-authored 70 publications receiving 6324 citations.
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Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Journal ArticleDOI
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
M. Juliana McElrath,M. Juliana McElrath,Stephen C. De Rosa,Stephen C. De Rosa,Zoe Moodie,Sheri Dubey,Lisa Kierstead,Holly Janes,Olivier D. Defawe,Donald K. Carter,John Hural,Rama Akondy,Susan Buchbinder,Michael N. Robertson,Devan V. Mehrotra,Steven G. Self,Steven G. Self,Lawrence Corey,Lawrence Corey,John W. Shiver,Danilo R. Casimiro +20 more
TL;DR: Consistent with previous trials, the MRKAd5 HIV-1 gag/pol/nef vaccine was highly immunogenic for inducing HIV-specific CD8+ T cells and suggest that future candidate vaccines have to elicit responses that either exceed in magnitude or differ in breadth or function from those recorded in this trial.
Journal ArticleDOI
Prevention of tuberculosis in macaques after intravenous BCG immunization
Patricia A. Darrah,Joseph J. Zeppa,Pauline Maiello,Joshua A Hackney,Marc H. Wadsworth,Marc H. Wadsworth,Marc H. Wadsworth,Travis K. Hughes,Travis K. Hughes,Travis K. Hughes,Supriya Pokkali,Phillip A. Swanson,Nicole L. Grant,Mark Rodgers,Megha Kamath,Chelsea M Causgrove,Dominick Laddy,Aurelio Bonavia,Danilo R. Casimiro,Philana Ling Lin,Edwin Klein,Alexander G. White,Charles A. Scanga,Alex K. Shalek,Mario Roederer,JoAnne L. Flynn,Robert A. Seder +26 more
TL;DR: The finding that intravenous BCG prevents or substantially limits Mtb infection in highly susceptible rhesus macaques has important implications for vaccine delivery and clinical development, and provides a model for defining immune correlates and mechanisms of vaccine-elicited protection against tuberculosis.
Journal ArticleDOI
Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques
Daria J. Hazuda,Steven D. Young,James P. Guare,Neville J. Anthony,Robert P. Gomez,John S. Wai,Joseph P. Vacca,Larry Handt,Sherri L. Motzel,Hilton J. Klein,Geethanjali Dornadula,Robert M. Danovich,Marc V. Witmer,Keith A. Wilson,Lynda Tussey,William A. Schleif,Lori S. Gabryelski,Lixia Jin,Michael D. Miller,Danilo R. Casimiro,Emilio A. Emini,John W. Shiver +21 more
TL;DR: These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.