F
Frank Buxton
Researcher at Novartis
Publications - 30
Citations - 2475
Frank Buxton is an academic researcher from Novartis. The author has contributed to research in topics: Gene & Aspergillus nidulans. The author has an hindex of 19, co-authored 30 publications receiving 2259 citations.
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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
E. Robert McDonald,Antoine de Weck,Michael R. Schlabach,Eric Billy,Konstantinos J. Mavrakis,Gregory R. Hoffman,Dhiren Belur,Deborah Castelletti,Elizabeth Frias,Kalyani Gampa,Javad Golji,Iris Kao,Li Li,Philippe Megel,Thomas A. Perkins,Nadire Ramadan,David A. Ruddy,Serena J. Silver,Sosathya Sovath,Mark Stump,Odile Weber,Roland Widmer,Jianjun Yu,Kristine Yu,Yingzi Yue,Dorothee Abramowski,Elizabeth Ackley,Rosemary Barrett,Joel Berger,Julie L. Bernard,Rebecca Billig,Saskia M. Brachmann,Frank Buxton,Roger Caothien,Justina X. Caushi,Franklin Chung,Marta Cortes-Cros,Rosalie deBeaumont,Clara Delaunay,Aurore Desplat,William Duong,Donald A. Dwoske,Richard S. Eldridge,Ali Farsidjani,Fei Feng,JiaJia Feng,Daisy Flemming,William C. Forrester,Giorgio G. Galli,Zhenhai Gao,François Gauter,Veronica Gibaja,Kristy Haas,Marc Hattenberger,Tami Hood,Kristen Hurov,Zainab Jagani,Mathias Jenal,Jennifer Johnson,Michael D. Jones,Avnish Kapoor,Joshua M. Korn,Jilin Liu,Qiumei Liu,Shumei Liu,Yue Liu,Alice T. Loo,Kaitlin J. Macchi,Typhaine Martin,Gregory McAllister,A. B. Meyer,Sandra Mollé,Raymond Pagliarini,Tanushree Phadke,Brian Repko,Tanja Schouwey,Frances Shanahan,Qiong Shen,Christelle Stamm,Christine Stephan,Volker M. Stucke,Ralph Tiedt,Malini Varadarajan,Kavitha Venkatesan,Alberto C. Vitari,Marco Wallroth,Jan Weiler,Jing Zhang,Craig Mickanin,Vic E. Myer,Jeffery A. Porter,Albert Lai,Hans Bitter,Emma Lees,Nicholas Keen,Audrey Kauffmann,Frank Stegmeier,Francesco Hofmann,Tobias Schmelzle,William R. Sellers +99 more
TL;DR: A large-scale RNAi screen is conducted in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features.
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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
Vadim Iourgenko,Wenjun Zhang,Craig Mickanin,Ira Daly,Can Jiang,Jonathan M. Hexham,Anthony P. Orth,Loren Miraglia,Jodi Meltzer,Dan Garza,Gung-Wei Chirn,Elizabeth McWhinnie,Dalia Cohen,Joanne Skelton,Robert D. Terry,Yang Yu,Dale L. Bodian,Frank Buxton,Jian Zhu,Chuanzheng Song,Mark Labow +20 more
TL;DR: TORCs represent a family of highly conserved CREB coactivators that may control the potency and specificity of CRE-mediated responses and represent an unbiased method for systematically determining gene function in mammalian cells.
Journal ArticleDOI
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Gregory R. Hoffman,Rami Rahal,Frank Buxton,Kay Xiang,Gregory McAllister,Elizabeth Frias,Linda Bagdasarian,Janina Huber,Alicia Lindeman,Dongshu Chen,Rodrigo Romero,Nadire Ramadan,Tanushree Phadke,Kristy Haas,Mariela Jaskelioff,Boris G. Wilson,Matthew J. Meyer,Veronica Saenz-Vash,Huili Zhai,Vic E. Myer,Jeffery A. Porter,Nicholas Keen,Margaret E. McLaughlin,Craig Mickanin,Charles W. M. Roberts,Frank Stegmeier,Zainab Jagani +26 more
TL;DR: This study provides important mechanistic insight into the BRM/BRG1 synthetic lethal relationship, shows this finding translates in vivo, and highlights BRM as a promising therapeutic target for the treatment BRG1-mutant cancers.
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Role of the cysteine protease cathepsin S in neuropathic hyperalgesia
Jane Barclay,Anna K. Clark,Pam Ganju,Clive Gentry,Clive Gentry,Sadhana Patel,Glen Wotherspoon,Frank Buxton,Chuanzheng Song,Jakir Hussain Ullah,Janet Winter,Alyson Fox,Stuart Bevan,Stuart Bevan,Marzia Malcangio,Marzia Malcangio +15 more
TL;DR: The results demonstrate a pro‐nociceptive effect of CatS and indicate that endogenous CatS released by peripheral macrophages contributes to the maintenance of neuropathic hyperalgesia following nerve injury.
Journal ArticleDOI
Transformation of Aspergillus niger using the argB gene of Aspergillus nidulans
TL;DR: A mutant of Aspergillus niger defective in ornithine transcarbamylase function was transformed with plasmids carrying a functional copy of the argB gene of As pergilli nidulans after treatment of spheroplasts in the presence of polyethylene glycol and calcium ions to insert any gene into the genome of A. niger.