Dan Huang

TL;DR: A major role for CD8 T cells in anti-tuberculosis immunity is demonstrated, and the view that CD 8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics is supported.

TL;DR: It is shown that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8+ T cells and that blockade ofCD244 signaling enhances production of IFN-γ and TNF-α.

TL;DR: Following a high-dose intrabronchial challenge with virulent M. tuberculosis, mc(2)6020-vaccinates were afforded a level of protection intermediate between that elicited by BCG vaccination and no vaccination, but survival did not differ among the groups.

TL;DR: Data support a rationale for conducting further studies of the γδ T-cell-targeted treatment of established TB, which might ultimately help explore single or adjunctive phosphoantigen expansion of Vγ2Vδ2 T- cell subset as intervention of MDR-tuberculosis or HIV-related tuberculosis.

TL;DR: A previously unknown mechanism for T-cell immune responses regulated by Tim-3 is uncovered, and findings may have implications for potential immune intervention in TB.