Z
Zheng W. Chen
Researcher at University of Illinois at Chicago
Publications - 90
Citations - 3258
Zheng W. Chen is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 30, co-authored 89 publications receiving 2767 citations. Previous affiliations of Zheng W. Chen include Chinese Academy of Sciences & Pasteur Institute.
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Journal ArticleDOI
A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis
Crystal Y. Chen,Dan Huang,Richard Wang,Ling Shen,Gucheng Zeng,Shuyun Yao,Yun Shen,Lisa Halliday,Jeff Fortman,Milton M. McAllister,Jim Estep,Robert E. Hunt,Daphne Vasconcelos,George Du,Steven A. Porcelli,Michelle H. Larsen,William R. Jacobs,Barton F. Haynes,Norman L. Letvin,Zheng W. Chen +19 more
TL;DR: A major role for CD8 T cells in anti-tuberculosis immunity is demonstrated, and the view that CD 8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics is supported.
Journal ArticleDOI
Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.
Yang Wang,Huiling Zhong,Xiaodan Xie,Crystal Y. Chen,Dan Huang,Ling Shen,Hui Zhang,Zheng W. Chen,Gucheng Zeng +8 more
TL;DR: It is shown that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8+ T cells and that blockade ofCD244 signaling enhances production of IFN-γ and TNF-α.
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Folate-Chitosan Nanoparticles Loaded with Ursolic Acid Confer Anti-Breast Cancer Activities in vitro and in vivo
Hua Jin,Jiang Pi,Fen Yang,Jinhuan Jiang,Xiaoping Wang,Haihua Bai,Mingtao Shao,Lei Huang,Haiyan Zhu,Peihui Yang,Lihua Li,Ting Li,Jiye Cai,Jiye Cai,Zheng W. Chen +14 more
TL;DR: It is demonstrated that a nanoparticle-based drug carrier composed of chitosan, UA and folate could effectively diminish off-target effects and increase local drug concentrations of UA and suggested that FA-CS-UA-NPs could further be explored as an anti-cancer drug candidate.
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Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates
Michelle H. Larsen,Karolin Biermann,Bing Chen,Tsungda Hsu,Vasan K. Sambandamurthy,Andrew A. Lackner,Pyone P. Aye,Peter J. Didier,Dan Huang,Linyun Shao,Huiyong Wei,Norman L. Letvin,Richard Frothingham,Barton F. Haynes,Zheng W. Chen,William R. Jacobs +15 more
TL;DR: Following a high-dose intrabronchial challenge with virulent M. tuberculosis, mc(2)6020-vaccinates were afforded a level of protection intermediate between that elicited by BCG vaccination and no vaccination, but survival did not differ among the groups.
Journal ArticleDOI
Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates
Crystal Y. Chen,Shuyu Yao,Shuyu Yao,Dan Huang,Huiyong Wei,Helene Sicard,Gucheng Zeng,Hassan Jomaa,Michelle H. Larsen,William R. Jacobs,Richard Wang,Norman L. Letvin,Yun Shen,Liyou Qiu,Ling Shen,Zheng W. Chen +15 more
TL;DR: Data support a rationale for conducting further studies of the γδ T-cell-targeted treatment of established TB, which might ultimately help explore single or adjunctive phosphoantigen expansion of Vγ2Vδ2 T- cell subset as intervention of MDR-tuberculosis or HIV-related tuberculosis.