Danchen Wang

TL;DR: It is shown that the hypercitrullination of histones by PAD4 mediates chromatin decondensation in granulocytes/neutrophils, and citrullinations of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures.

TL;DR: HNCO loss in CID spectra provides a novel diagnostic marker for citrullination, and its utility was demonstrated by the discovery of Arg197 as the specific site of citruLLination on nucleophosmin upon peptidylarginine deiminase 4 treatment.

TL;DR: The roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of AD are summarized and the necessity to focus on exosome from biological fluids and specific cells that are less invasive to target is emphasized.

TL;DR: In this article , a simple and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was proposed for the quantification of total homocysteine (tHcy) and methylmalonic acid (MMA) with the efficient separation of succinic acid (SA) in human serum and urine.

TL;DR: The results of these algorithms were compared to those of RIs established using healthy older adults recruited following strict inclusion and exclusion criteria and the bias ratio (BR) matrix was used to compare the limits of different algorithms as discussed by the authors .