Sarah Correll

TL;DR: It is shown that the hypercitrullination of histones by PAD4 mediates chromatin decondensation in granulocytes/neutrophils, and citrullinations of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures.

TL;DR: The results show that the 2-start zigzag topology and the type of linker DNA bending that defines solenoid models may be simultaneously present in a structurally heteromorphic chromatin fiber with uniform 30 nm diameter and suggest that dynamic linkerDNA bending by linker histones and divalent cations in vivo may mediate the transition between tight nucleosome packing within discrete 30-nm fibers and self-associated higher-order chromosomal forms.

TL;DR: It is suggested that mouse NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones.

TL;DR: The results suggest that the NRL may direct chromatin higher‐order structure into either a nucleosome position‐dependent folding for short NRLs typical of transcribed genes or an architectural factor‐ dependent folding typical of longer NRLs prevailing in eukaryotic heterochromatin.