P
Pingxin Li
Researcher at Pennsylvania State University
Publications - 8
Citations - 2869
Pingxin Li is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Histone & Histone citrullination. The author has an hindex of 7, co-authored 8 publications receiving 2425 citations. Previous affiliations of Pingxin Li include Foundation University, Islamabad.
Papers
More filters
Journal ArticleDOI
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
Yanming Wang,Ming‐ming Li,Sonja C. Stadler,Sonja C. Stadler,Sarah Correll,Pingxin Li,Danchen Wang,Ryo Hayama,Lauriebeth Leonelli,Hyunsil Han,Sergei A. Grigoryev,C. David Allis,Scott A. Coonrod +12 more
TL;DR: It is shown that the hypercitrullination of histones by PAD4 mediates chromatin decondensation in granulocytes/neutrophils, and citrullinations of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures.
Journal ArticleDOI
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
TL;DR: It is found that citrullination decreased the bacterial killing activity of histones and nucleosomes, which suggests that PAD4 mainly plays a role in chromatin decondensation to form NETs instead of increasing histone-mediated bacterial killing.
Journal ArticleDOI
Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4
Pingxin Li,Hongjie Yao,Zhiqiang Zhang,Ming Li,Yuan Luo,Paul R. Thompson,David S. Gilmour,Yanming Wang +7 more
TL;DR: It is reported that peptidylarginine deiminase 4, a histone citrullination enzyme, is involved in the repression of p53 target genes.
Journal ArticleDOI
Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis
Hongjie Yao,Pingxin Li,Bryan J. Venters,Suting Zheng,Paul R. Thompson,B. Franklin Pugh,Yanming Wang +6 more
TL;DR: OKL38 is identified as a novel p53 target gene that is regulated by PAD4 and plays a role in apoptosis, and it is found that OKL38 induces apoptosis through localization to mitochondria and induction of cytochrome c release.
Journal ArticleDOI
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity
Yuji Wang,Yuji Wang,Pingxin Li,Shu Wang,Jing Hu,Xiangyun Amy Chen,Jianhui Wu,Jianhui Wu,Megan Fisher,Kira Oshaben,Na Zhao,Ying Gu,Dong Wang,Gong Chen,Yanming Wang +14 more
TL;DR: PAD4 regulates the mTORC1 signaling pathway and that PAD inhibitors are potential anticancer reagents that activate tumor suppressor gene expression alone or in combination with histone deacetylase inhibitors.