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Sonja C. Stadler
Researcher at Rockefeller University
Publications - 9
Citations - 3438
Sonja C. Stadler is an academic researcher from Rockefeller University. The author has contributed to research in topics: Histone & Transcription factor. The author has an hindex of 7, co-authored 8 publications receiving 2978 citations. Previous affiliations of Sonja C. Stadler include Leipzig University & Cornell University.
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Journal ArticleDOI
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
Yanming Wang,Ming‐ming Li,Sonja C. Stadler,Sonja C. Stadler,Sarah Correll,Pingxin Li,Danchen Wang,Ryo Hayama,Lauriebeth Leonelli,Hyunsil Han,Sergei A. Grigoryev,C. David Allis,Scott A. Coonrod +12 more
TL;DR: It is shown that the hypercitrullination of histones by PAD4 mediates chromatin decondensation in granulocytes/neutrophils, and citrullinations of biochemically defined avian nucleosome arrays inhibits their compaction by the linker histone H5 to form higher order chromatin structures.
Journal ArticleDOI
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
Journal ArticleDOI
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
TL;DR: It is found that the ATRX–Daxx complex is bound to telomeric chromatin, and that both components of this complex are required for H3.3 deposition at telomeres in murine embryonic stem cells (ESCs).
Journal ArticleDOI
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
Thomas A. Milne,Jaehoon Kim,Gang Greg Wang,Sonja C. Stadler,Venkatesha Basrur,Sarah J. Whitcomb,Zhanxin Wang,Alexander J. Ruthenburg,Kojo S.J. Elenitoba-Johnson,Robert G. Roeder,C. David Allis +10 more
TL;DR: An essential MLL1 recruitment domain is identified that includes the CXXC domain and PHD fingers and is controlled by direct interactions with the PAF elongation complex and H3K4Me2/3.
Journal ArticleDOI
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells
Sonja C. Stadler,C. Theresa Vincent,Victor D. Fedorov,Antonia Patsialou,Brian D. Cherrington,Joseph J. Wakshlag,Sunish Mohanan,Barry M. Zee,Xuesen Zhang,Benjamin A. Garcia,John S. Condeelis,Anthony M. C. Brown,Scott A. Coonrod,C. David Allis +13 more
TL;DR: It is proposed that PAD4-mediated citrullination of GSK3β is a unique posttranslational modification that regulates its nuclear localization and thereby plays a critical role in maintaining an epithelial phenotype.