S
Steven S. Gross
Researcher at Cornell University
Publications - 224
Citations - 20039
Steven S. Gross is an academic researcher from Cornell University. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 67, co-authored 215 publications receiving 18574 citations. Previous affiliations of Steven S. Gross include University of Texas Health Science Center at San Antonio & Hokkaido University.
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Journal ArticleDOI
Nitric Oxide: Pathophysiological Mechanisms
Steven S. Gross,Michael S. Wolin +1 more
TL;DR: This review summarizes the present knowledge of cellular events that lead to NO overproduction in mammalian systems and discusses reactions of NO that may contribute to cell damage or death.
Journal ArticleDOI
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
Jan Mauer,Xiaobing Luo,Alexandre Blanjoie,Xinfu Jiao,Anya V. Grozhik,Deepak P. Patil,Bastian Linder,Brian F. Pickering,Jean-Jacques Vasseur,Qiuying Chen,Steven S. Gross,Olivier Elemento,Françoise Debart,Megerditch Kiledjian,Samie R. Jaffrey +14 more
TL;DR: Using a transcriptome-wide map of m6Am, it is found that m 6Am-initiated transcripts are markedly more stable than mRNAs that begin with other nucleotides and that m6 am is selectively demethylated by fat mass and obesity-associated protein (FTO).
Journal ArticleDOI
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.
Robert G. Kilbourn,Steven S. Gross,Amal Jubran,James Adams,Owen W. Griffith,Roberto Levi,Robert F Lodato +6 more
TL;DR: It is suggested that excessive nitric oxide production mediates the hypotensive effect of TNF, a potent vasodilator initially characterized as endothelium-derived relaxing factor.
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
Jihye Yun,Edouard Mullarky,Edouard Mullarky,Changyuan Lu,Kaitlyn Bosch,Adam Kavalier,Keith Rivera,Jatin Roper,Iok In Christine Chio,Eugenia G. Giannopoulou,Carlo Rago,Ashlesha Muley,John M. Asara,Jihye Paik,Olivier Elemento,Zhengming Chen,Darryl J. Pappin,Lukas E. Dow,Nickolas Papadopoulos,Steven S. Gross,Lewis C. Cantley +20 more
TL;DR: It is found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C, due to increased uptake of the oxidized form of Vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter.
Journal ArticleDOI
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis.
Robert G. Kilbourn,Amal Jubran,Steven S. Gross,Owen W. Griffith,Roberto Levi,James Adams,Robert F. Lodato +6 more
TL;DR: The utility of nitric oxide synthesis inhibitors in endotoxic shock is demonstrated for the first time and it is suggested that such inhibitors may be of therapeutic value in the treatment of septic shock.