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Colin R. Butler
Researcher at University College London
Publications - 37
Citations - 1388
Colin R. Butler is an academic researcher from University College London. The author has contributed to research in topics: Transplantation & Stem cell. The author has an hindex of 12, co-authored 31 publications receiving 1073 citations. Previous affiliations of Colin R. Butler include University College Hospital & Great Ormond Street Hospital for Children NHS Foundation Trust.
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Journal ArticleDOI
Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study
Martin J. Elliott,Paolo De Coppi,Simone Speggiorin,Derek J. Roebuck,Colin R. Butler,Edward R. Samuel,Claire Crowley,Clare A. McLaren,Anja Fierens,David Vondrys,L.A. Cochrane,C.G. Jephson,Sam M. Janes,Nicholas J. Beaumont,Tristan A Cogan,Augustinus Bader,Alexander M. Seifalian,J. Justin Hsuan,Mark W. Lowdell,Martin A. Birchall +19 more
TL;DR: Follow-up of the first paediatric, stem-cell-based, tissue-engineered transplant shows potential for this technology but also highlights the need for further research.
Journal ArticleDOI
Tobacco smoking and somatic mutations in human bronchial epithelium
Kenichi Yoshida,Kate H.C. Gowers,Henry Lee-Six,Deepak P. Chandrasekharan,Tim H. H. Coorens,Elizabeth F. Maughan,Kathryn Beal,Andrew Menzies,Fraser R. Millar,Elizabeth Anderson,Sarah E. Clarke,Adam Pennycuick,Ricky Thakrar,Ricky Thakrar,Colin R. Butler,Colin R. Butler,Nobuyuki Kakiuchi,Tomonori Hirano,Robert E. Hynds,Michael R. Stratton,Inigo Martincorena,Sam M. Janes,Sam M. Janes,Peter J. Campbell,Peter J. Campbell +24 more
TL;DR: W Whole-genome sequencing of normal bronchial epithelium from 16 individuals shows that tobacco smoking increases genomic heterogeneity, mutational burden and driver mutations, whereas stopping smoking promotes replenishment of the epithelia with near-normal cells.
Journal ArticleDOI
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering
Colin R. Butler,Robert E. Hynds,Kate H.C. Gowers,Dani Do Hyang Lee,James Brown,Claire Crowley,Vitor H. Teixeira,Claire Smith,Luca Urbani,Nicholas Hamilton,Ricky Thakrar,Helen Booth,Martin A. Birchall,Paolo De Coppi,Adam Giangreco,Christopher O'Callaghan,Sam M. Janes +16 more
TL;DR: The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.
Journal ArticleDOI
Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study
Nicholas Hamilton,Mazyar Kanani,Derek J. Roebuck,Richard Hewitt,Raul Cetto,Emily J. Culme-Seymour,Ed C. Toll,Alister J. Bates,A. Comerford,Clare A. McLaren,Colin R. Butler,C. Crowley,Denise McIntyre,Neil J. Sebire,Sam M. Janes,Christopher O'Callaghan,Christopher E. Mason,P De Coppi,Mark W. Lowdell,Martin J. Elliott,Martin A. Birchall +20 more
TL;DR: The long‐term viability of a decellularized tissue‐engineered trachea within a child is demonstrated and further research is needed to develop bioengineered pediatric tracheal replacements with lower morbidity, better biomechanics and lower costs.
Journal ArticleDOI
β‐Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial–mesenchymal transition
Adam Giangreco,L Lu,Charles Vickers,Vitor H. Teixeira,Karen R. Groot,Colin R. Butler,Ekaterina V. Ilieva,P. Jeremy George,Andrew G. Nicholson,Elizabeth K. Sage,Fiona M. Watt,Sam M. Janes +11 more
TL;DR: Overall, the data show that airway basal cell β‐catenin determines cell fate and its mis‐expression is associated with the development of human lung cancer.