R
Ricky Thakrar
Researcher at University College London
Publications - 36
Citations - 4965
Ricky Thakrar is an academic researcher from University College London. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 11, co-authored 26 publications receiving 3333 citations. Previous affiliations of Ricky Thakrar include Francis Crick Institute & University College Hospital.
Papers
More filters
Journal ArticleDOI
Tracking the Evolution of Non–Small-Cell Lung Cancer
Mariam Jamal-Hanjani,Gareth A. Wilson,Nicholas McGranahan,Nicolai Juul Birkbak,Thomas B.K. Watkins,Selvaraju Veeriah,Seema Shafi,Diana Johnson,Richard Mitter,Rachel Rosenthal,Max Salm,Stuart Horswell,Mickael Escudero,Nik Matthews,Andrew Rowan,Tim Chambers,David A. Moore,Samra Turajlic,Hang Xu,Siow Ming Lee,Martin Forster,Tanya Ahmad,Crispin T. Hiley,Christopher Abbosh,Mary Falzon,Elaine Borg,Teresa Marafioti,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid A. Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen Davies,Stefan C. Dentro,Philippe Taniere,Brendan O'Sullivan,Helen Lowe,John A. Hartley,Natasha Iles,Harriet Bell,Yenting Ngai,Jacqui Shaw,Javier Herrero,Zoltan Szallasi,Roland F. Schwarz,Aengus Stewart,Sergio A. Quezada,John Le Quesne,Peter Van Loo,Caroline Dive,Allan Hackshaw,Charles Swanton +82 more
TL;DR: Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
Journal ArticleDOI
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Christopher Abbosh,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Mariam Jamal-Hanjani,Tudor Constantin,Raheleh Salari,John Le Quesne,David A. Moore,Selvaraju Veeriah,Rachel Rosenthal,Teresa Marafioti,Eser Kirkizlar,Thomas B.K. Watkins,Thomas B.K. Watkins,Nicholas McGranahan,Nicholas McGranahan,Sophia Ward,Sophia Ward,Luke Martinson,Joan Riley,Francesco Fraioli,Maise Al Bakir,Eva Grönroos,Francisco Zambrana,Raymondo Endozo,Wenya Linda Bi,Wenya Linda Bi,Fiona M. Fennessy,Fiona M. Fennessy,Nicole Sponer,Diana Johnson,Joanne Laycock,Seema Shafi,Justyna Czyzewska-Khan,Andrew Rowan,Tim Chambers,Nik Matthews,Nik Matthews,Samra Turajlic,Samra Turajlic,Crispin T. Hiley,Crispin T. Hiley,Siow Ming Lee,Martin Forster,Tanya Ahmad,Mary Falzon,Elaine Borg,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Dina Hafez,Ashwini Naik,Apratim Ganguly,Stephanie Kareht,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith M. Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen E. Davies,Dahmane Oukrif,Ayse U. Akarca,John A. Hartley,Helen Lowe,Sara Lock,Natasha Iles,Harriet Bell,Yenting Ngai,Greg Elgar,Zoltan Szallasi,Zoltan Szallasi,Zoltan Szallasi,Roland F. Schwarz,Javier Herrero,Aengus Stewart,Sergio A. Quezada,Karl S. Peggs,Peter Van Loo,Peter Van Loo,Caroline Dive,Caroline Dive,C. Jimmy Lin,Matthew Rabinowitz,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Allan Hackshaw,Jacqui Shaw,Bernhard Zimmermann,Charles Swanton,Charles Swanton +119 more
TL;DR: It is shown that phylogenetic ct DNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Journal ArticleDOI
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
Nicholas McGranahan,Rachel Rosenthal,Crispin T. Hiley,Crispin T. Hiley,Andrew J. Rowan,Thomas B.K. Watkins,Gareth A. Wilson,Gareth A. Wilson,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Selvaraju Veeriah,Peter Van Loo,Peter Van Loo,Javier Herrero,Charles Swanton,Charles Swanton,Mariam Jamal-Hanjani,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Pat Gorman,Robert E. Hynds,Gareth A. Wilson,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Andrew Rowan,Hang Xu,Samra Turajlic,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,Kroopa Joshi,Andrew Furness,Assma Ben Aissa,Yien Ning Sophia Wong,Andy Georgiou,Sergio A. Quezada,John A. Hartley,Helen Lowe,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Teresa Marafioti,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan K. Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jordan,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw,Hugo J.W.L. Aerts,Stefan C. Dentro,Christophe Dessimoz +219 more
TL;DR: It is found that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.
Journal ArticleDOI
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas,Andrew Furness,Andrew Furness,Isabelle Solomon,Kroopa Joshi,Kroopa Joshi,Leila Mekkaoui,Marta H. Lesko,Enrique Miranda Rota,Rony Dahan,Andrew Georgiou,Anna Sledzinska,Assma Ben Aissa,Dafne Franz,Mariana Werner Sunderland,Yien Ning Sophia Wong,Jake Y. Henry,Tim O'Brien,David Nicol,Ben Challacombe,Stephen A. Beers,Samra Turajlic,Martin Gore,James Larkin,Charles Swanton,Kerry A. Chester,Martin Pule,Jeffrey V. Ravetch,Teresa Marafioti,Karl S. Peggs,Sergio A. Quezada,Lavinia Spain,Andrew Wotherspoon,Nicholas Francis,Myles Smith,Dirk C. Strauss,Andrew J. Hayes,Aspasia Soultati,Mark Stares,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Mariam Jamal-Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert E. Hynds,Gareth A. Wilson,Nicolai Juul Birkbak,Thomas B.K. Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Van Loo,Andrew Rowan,Hang Xu,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,John A. Hartley,Helen Lowe,Javier Herrero,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Natasha Iles,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jorda,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw +250 more
TL;DR: Use of an anti‐CD25 antibody with enhanced binding to activating Fc&ggr;Rs led to effective depletion of tumor‐infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.
Journal ArticleDOI
Tobacco smoking and somatic mutations in human bronchial epithelium
Kenichi Yoshida,Kate H.C. Gowers,Henry Lee-Six,Deepak P. Chandrasekharan,Tim H. H. Coorens,Elizabeth F. Maughan,Kathryn Beal,Andrew Menzies,Fraser R. Millar,Elizabeth Anderson,Sarah E. Clarke,Adam Pennycuick,Ricky Thakrar,Ricky Thakrar,Colin R. Butler,Colin R. Butler,Nobuyuki Kakiuchi,Tomonori Hirano,Robert E. Hynds,Michael R. Stratton,Inigo Martincorena,Sam M. Janes,Sam M. Janes,Peter J. Campbell,Peter J. Campbell +24 more
TL;DR: W Whole-genome sequencing of normal bronchial epithelium from 16 individuals shows that tobacco smoking increases genomic heterogeneity, mutational burden and driver mutations, whereas stopping smoking promotes replenishment of the epithelia with near-normal cells.