D
Daniel Blessborn
Researcher at University of Oxford
Publications - 29
Citations - 1106
Daniel Blessborn is an academic researcher from University of Oxford. The author has contributed to research in topics: Piperaquine & Malaria. The author has an hindex of 16, co-authored 28 publications receiving 948 citations. Previous affiliations of Daniel Blessborn include Uppsala University & Mahidol University.
Papers
More filters
Journal ArticleDOI
Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study
Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Sivanna Mao,Chantha Sopha,Baramey Sam,Dalin Dek,Vorleak Try,Roberto Amato,Roberto Amato,Daniel Blessborn,Daniel Blessborn,Lijiang Song,Lijiang Song,Gregory Tullo,Michael P. Fay,Jennifer M. Anderson,Joel Tarning,Joel Tarning,Rick M. Fairhurst +20 more
TL;DR: In Cambodia, artesunate plus mefloquine may be a viable option to treat dihydroartemisinin-piperaquine failures, and a more effective first-line ACT in areas where dihydrodynamic failures are common, and the use of single low-dose primaquine to eliminate circulating gametocytes is needed in Areas where artemisin in and ACT resistance is prevalent.
Journal ArticleDOI
Development and validation of an automated solid-phase extraction and liquid chromatographic method for determination of lumefantrine in capillary blood on sampling paper
Daniel Blessborn,Susanne Römsing,Susanne Römsing,Anna Annerberg,Daniel Sundquist,Anders Björkman,Niklas Lindegardh,Niklas Lindegardh,Yngve Bergqvist,Yngve Bergqvist +9 more
TL;DR: A bioanalytical method for the determination of lumefantrine in 100 microl blood applied onto sampling paper, by solid-phase extraction and liquid chromatography, has been developed and validated and could be estimated accurately enough to assess bioavailability and treatment compliance on day 7 (i.e. 4 days after the last dose) after a standard regimen with the lumefanrine/artemether combination.
Journal ArticleDOI
Efficacy and Effectiveness of Artemether-Lumefantrine after Initial and Repeated Treatment in Children < 5 Years of Age with Acute Uncomplicated Plasmodium falciparum Malaria in Rural Tanzania: A Randomized Trial
Billy Ngasala,Billy Ngasala,Maja Malmberg,Anja M. Carlsson,Pedro Eduardo Ferreira,Pedro Eduardo Ferreira,Max Petzold,Daniel Blessborn,Daniel Blessborn,Yngve Bergqvist,Yngve Bergqvist,José Pedro Gil,José Pedro Gil,José Pedro Gil,Zul Premji,Anders Björkman,Andreas Mårtensson,Andreas Mårtensson +17 more
TL;DR: Artemether-lumefantrine was highly efficacious even after unsupervised administration, despite significantly lower lumefanrine concentrations, compared with concentration achieved with supervised intake, and was well-tolerated and safe after initial and repeated treatment.
A bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma
TL;DR: A bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma is presented in this paper.
Journal ArticleDOI
Development and validation of a bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma
Niklas Lindegardh,Anna Annerberg,Daniel Blessborn,Yngve Bergqvist,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White +7 more
TL;DR: A bioanalytical method for the determination of lumefantrine and its metabolite desbutyl-lumefanrine in plasma by solid-phase extraction (SPE) and liquid chromatography has been developed and different amounts of lipids in plasma did not affect the absolute recovery of LF or DLF.