D
Daniel D. MacDonald
Researcher at Cornell University
Publications - 5
Citations - 3054
Daniel D. MacDonald is an academic researcher from Cornell University. The author has contributed to research in topics: Vascular endothelial growth factor A & Progenitor cell. The author has an hindex of 4, co-authored 5 publications receiving 2787 citations. Previous affiliations of Daniel D. MacDonald include National Institutes of Health.
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Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
Journal ArticleDOI
Neoangiogenesis contributes to the development of hemophilic synovitis.
Suchitra S. Acharya,Rosandra N. Kaplan,Daniel D. MacDonald,Daniel D. MacDonald,Oluwa T. Fabiyi,Oluwa T. Fabiyi,Donna DiMichele,David Lyden,David Lyden,David Lyden +9 more
TL;DR: Evidence of local and systemic angiogenic response in hemophilic subjects with recurrent hemarthroses is provided, suggesting a potential to develop surrogate biologic markers to identify the onset and progression of hemophilia synovitis.
Journal ArticleDOI
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.
Anxo Vidal,Anxo Vidal,Stergios Zacharoulis,Stergios Zacharoulis,Wenjun Guo,David R. Shaffer,Filippo G Giancotti,Anna H. Bramley,Carmen de la Hoz,Kristian Jensen,Daniel Kato,Daniel D. MacDonald,Joseph Knowles,Nancy Yeh,Lawrence A. Frohman,Shahin Rafii,David Lyden,Andrew Koff +17 more
TL;DR: It is reported that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors, and it is suggested that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.
Journal ArticleDOI
A Role for Angiogenesis in Hemophilic Synovitis.
Suchitra S. Acharya,Daniel D. MacDonald,Donna DiMichele,Margaret W. Hilgartner,Daniel A. Greninger,Ilene Goldberg,David Lyden +6 more
Journal ArticleDOI
Kaplan et al. reply
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden,Jared Wels +21 more
TL;DR: It is shown that VEGFR1 knockdown in myelomonocytic cells eradicates micro- and macrometastases in a non-amputation/resection tumour model.