D
Daniel E. Gottschling
Researcher at Fred Hutchinson Cancer Research Center
Publications - 81
Citations - 15597
Daniel E. Gottschling is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Gene & Saccharomyces cerevisiae. The author has an hindex of 49, co-authored 79 publications receiving 14753 citations. Previous affiliations of Daniel E. Gottschling include University of Illinois at Chicago & University of Colorado Boulder.
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Journal ArticleDOI
Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae.
TL;DR: It is suggested that the age-associated increase in rDNA recombination is a response to increasing DNA replication stress generated in aging cells.
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Selective sorting and destruction of mitochondrial membrane proteins in aged yeast
TL;DR: A new mitochondrial degradation system that remodels the mitochondrial proteome of aged cells is identified, which selectively removes a subset of membrane proteins from the mitochondrial inner and outer membranes, while leaving the remainder of the organelle intact.
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Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.
TL;DR: Results indicate that telomere position effect can be alleviated without compromising chromosome stability, and two other essential chromosomal elements, centromeres and origins of replication, are eliminated.
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Heritable chromatin structure: Mapping “memory” in histones H3 and H4
Christine M. Smith,Zara W. Haimberger,Catherine O. Johnson,Alex J. Wolf,Philip R. Gafken,Zhongli Zhang,Mark R. Parthun,Daniel E. Gottschling +7 more
TL;DR: A genetic screen to isolate mutant alleles of the histones H3 and H4 genes that would “lock” telomeric marker genes into a silenced state discovered that each of these mutants had a dramatic reduction in the level of acetylation at lysine 12 within the histone H4 tail, which is proposed to serve as a “memory mark” for propagating the expression state of a telomersic gene.
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Recombination-induced tag exchange to track old and new proteins
Kitty F. Verzijlbergen,Victoria Menendez-Benito,Tibor van Welsem,Sjoerd J. van Deventer,Derek L. Lindstrom,Huib Ovaa,Jacques Neefjes,Daniel E. Gottschling,Fred van Leeuwen +8 more
TL;DR: RITE is widely applicable and allows probing spatiotemporal changes in protein properties by multiple methods and is validated by determining exchange of endogenous histones in chromatin by biochemical methods and by visualizing and quantifying replacement of old by new proteasomes in single cells by microscopy.