Daniel G. Taub

TL;DR: It is shown that adult neurons from Caenorhabditis elegans extrude large membrane-surrounded vesicles called exophers that can contain protein aggregates and organelles, and it is proposed that exophers are components of a conserved mechanism that constitutes a fundamental, but formerly unrecognized, branch of neuronal proteostasis and mitochondrial quality control.

TL;DR: Based on quantified performance metrics, the data suggest that selective targeted enrichment is preferable to whole-exome sequencing for genetic diagnostic testing of patients with inherited eye disorders.

TL;DR: Effectes were gene and tissue specific, indicating that tissue-specific metabolism is an important component of PCB disruption of TH action and that PCB metabolites interact in complex ways with the TR.

TL;DR: It is shown that the MT-binding domain is known to stabilize MT structures, and the S/P-rich region prevents F-actin destabilization in injured axon stumps, and Multifunctional DCXs thus represent potential targets for promoting both survival and regeneration of injured neurons.

TL;DR: A transcriptional program in C. elegans is described that regulates expression of an Ig domain protein, OIG-1, to control the timing of synaptic remodeling in DD and VD neurons.