J
Janey L. Wiggs
Researcher at Massachusetts Eye and Ear Infirmary
Publications - 292
Citations - 13714
Janey L. Wiggs is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Glaucoma & Open angle glaucoma. The author has an hindex of 60, co-authored 259 publications receiving 11479 citations. Previous affiliations of Janey L. Wiggs include University of Alabama at Birmingham & University of California, Berkeley.
Papers
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Journal ArticleDOI
Primary open-angle glaucoma.
Robert N. Weinreb,Christopher Kai-Shun Leung,Jonathan G Crowston,Felipe A. Medeiros,David S. Friedman,Janey L. Wiggs,Keith R Martin +6 more
TL;DR: Primary open-angle glaucoma (POAG) is the most common type and management of POAG includes topical drug therapies and surgery to reduce IOP, although new therapies targeting neuroprotection of RGCs and axonal regeneration are under development.
Journal ArticleDOI
Detectable clonal mosaicism from birth to old age and its relationship to cancer.
Cathy C. Laurie,Cecelia A. Laurie,Kenneth Rice,Kimberly F. Doheny,Leila R. Zelnick,Caitlin P. McHugh,Hua Ling,Kurt N. Hetrick,Elizabeth W. Pugh,Christopher I. Amos,Qingyi Wei,Li-E Wang,Jeffrey E. Lee,Kathleen C. Barnes,Nadia N. Hansel,Rasika A. Mathias,Denise Daley,Terri H. Beaty,Alan F. Scott,Ingo Ruczinski,Robert B. Scharpf,Laura J. Bierut,Sarah M. Hartz,Maria Teresa Landi,Neal D. Freedman,Lynn R. Goldin,David Ginsburg,Jun-Jun Li,Karl C. Desch,Sara S. Strom,William J. Blot,Lisa B. Signorello,Sue A. Ingles,Stephen J. Chanock,Sonja I. Berndt,Loic Le Marchand,Brian E. Henderson,Kristine R. Monroe,John A. Heit,Mariza de Andrade,Sebastian M. Armasu,Cynthia Regnier,William L. Lowe,M. Geoffrey Hayes,Mary L. Marazita,Eleanor Feingold,Jeffrey C. Murray,Mads Melbye,Bjarke Feenstra,Jae H. Kang,Janey L. Wiggs,Gail P. Jarvik,Andrew McDavid,Venkatraman E. Seshan,Daniel B. Mirel,Andrew Crenshaw,Nataliya Sharopova,Anastasia L. Wise,Jess Shen,David R. Crosslin,David M. Levine,Xiuwen Zheng,Jenna Udren,Siiri N. Bennett,Sarah C. Nelson,Stephanie M. Gogarten,Matthew P. Conomos,Patrick J. Heagerty,Teri A. Manolio,Louis R. Pasquale,Christopher A. Haiman,Neil E. Caporaso,Bruce S. Weir +72 more
TL;DR: Clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) is detected using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies to identify common deleted regions with genes previously associated with hematological cancers.
Journal ArticleDOI
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.
Michael G. Anderson,Richard S. Smith,Norman L. Hawes,Adriana Zabaleta,Bo Chang,Janey L. Wiggs,Simon W. M. John,Simon W. M. John +7 more
TL;DR: The rescue of IPD and ISA in D2 eyes with substantially decreased pigment production is supported, indicating that pigment production and mutant melanosomal protein genes may contribute to human pigmentary glaucoma.
Journal ArticleDOI
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
Yi Lu,Veronique Vitart,Kathryn P. Burdon,Chiea Chuen Khor,Yelena Bykhovskaya,Alireza Mirshahi,Alex W. Hewitt,Alex W. Hewitt,Demelza Koehn,Pirro G. Hysi,Wishal D. Ramdas,Tanja Zeller,Eranga N. Vithana,Belinda K. Cornes,Wan Ting Tay,E. Shyong Tai,Ching-Yu Cheng,Jianjun Liu,Jianjun Liu,Jia Nee Foo,Seang-Mei Saw,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson,David P. Dimasi,Richard A. Mills,Jenny Mountain,Wei Ang,René Hoehn,Virginie J. M. Verhoeven,Franz H. Grus,Roger C. W. Wolfs,Raphaële Castagné,Karl J. Lackner,Henriët Springelkamp,Jian Yang,Fridbert Jonasson,Dexter Y L Leung,Li J. Chen,Clement C Y Tham,Igor Rudan,Igor Rudan,Zoran Vatavuk,Caroline Hayward,Jane Gibson,Angela J. Cree,Alex MacLeod,Sarah Ennis,Ozren Polasek,Harry Campbell,James F. Wilson,Ananth C. Viswanathan,Brian W Fleck,Xiaohui Li,David S. Siscovick,Kent D. Taylor,Jerome I. Rotter,Seyhan Yazar,Megan Ulmer,Jun Li,Brian L. Yaspan,Ayse Bilge Ozel,Julia E. Richards,Sayoko E. Moroi,Jonathan L. Haines,Jae H. Kang,Louis R. Pasquale,Louis R. Pasquale,R. Rand Allingham,Allison E. Ashley-Koch,Paul Mitchell,Jie Jin Wang,Alan F. Wright,Craig E. Pennell,Tim D. Spector,Terri L. Young,Terri L. Young,Caroline C W Klaver,Nicholas G. Martin,Grant W. Montgomery,Michael G. Anderson,Tin Aung,Colin E. Willoughby,Janey L. Wiggs,Chi P. Pang,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andrew J. Lotery,Christopher J Hammond,Cornelia M. van Duijn,Michael A. Hauser,Yaron S. Rabinowitz,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Jamie E Craig,Stuart MacGregor,Tien Yin Wong,Tien Yin Wong +98 more
TL;DR: A meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance showed that 2 CCT-associated loci conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls.
Journal ArticleDOI
A simple procedure for resolution of Escherichia coli RNA polymerase holoenzyme from core polymerase.
TL;DR: A method for the isolation of homogeneous Escherichia coli RNA polymerase holoenzyme is described, in which only small amounts of σ subunit are lost and RNA polymerases holoenzymes are well separated from the core polymerase.