Daniel Gigot

TL;DR: It is demonstrated that the murine homologue of the previously identified human "pre‐B‐cell colony‐enhancing factor" (PBEF) gene coding for a putative cytokine has been identified by screening a subtractive library enriched in genes expressed in activated T lymphocytes, and NAD biosynthesis may play an important role in lymphocyte activation.

TL;DR: It is proposed that integration host factor and CarP/PepA-induced structural modifications in the carAB control region cause conformational changes required to assemble a pyrimidine-specific nucleo-protein regulatory complex.

TL;DR: The study of carbamoylphosphate synthesizing activities of these mutants and the combination of car mutations in various in vivo as well as in vitro complementation tests lead to the conclusion that car contains two genes: carA, covering the left part of the locus and coding for the “glutamine subunit” of the enzyme; carB, to the right, governing the synthesis of the heavy subunit of the enzymes.

TL;DR: ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene, and the homology observed between the two proteins suggests a common origin.

TL;DR: The data obtained suggest that derivatives of both cytidine and uridine participate in the repression of CPSase, and suggests that this control is mediated through the concerted effects of regulatory elements specific for the arginine and pyrimidine pathways.