D
Daniel J Gachotte
Researcher at Dow AgroSciences
Publications - 28
Citations - 3560
Daniel J Gachotte is an academic researcher from Dow AgroSciences. The author has contributed to research in topics: Ergosterol & Sterol. The author has an hindex of 14, co-authored 28 publications receiving 3449 citations. Previous affiliations of Daniel J Gachotte include Indiana University – Purdue University Indianapolis & Dow Chemical Company.
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Journal ArticleDOI
Functional Discovery via a Compendium of Expression Profiles
Timothy P. Hughes,Matthew J. Marton,Allan R. Jones,Christopher J. Roberts,Roland Stoughton,Christopher D. Armour,Holly A. Bennett,Ernest M. Coffey,Hongyue Dai,Yudong D. He,Matthew J. Kidd,Amy M King,Michael R. Meyer,David J. Slade,Pek Yee Lum,Sergey B. Stepaniants,Daniel D. Shoemaker,Daniel J Gachotte,Kalpana Chakraburtty,Julian A. Simon,Martin Bard,Stephen H. Friend +21 more
TL;DR: A reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae is constructed, and it is shown that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles.
Journal ArticleDOI
The Protein Kinase SnRK2.6 Mediates the Regulation of Sucrose Metabolism and Plant Growth in Arabidopsis
Zhifu Zheng,Xiaoping Xu,Rodney A. Crosley,Scott A. Greenwalt,Yuejin Sun,Beth Blakeslee,Lizhen Wang,Weiting Ni,Megan S. Sopko,Chenglin Yao,Kerrm Y. Yau,Stephanie Burton,Meibao Zhuang,David McCaskill,Daniel J Gachotte,Mark A. Thompson,Thomas W. Greene +16 more
TL;DR: It is shown that SnRK2.6, previously identified as crucial in the control of stomatal aperture by abscisic acid (ABA), has a broad expression pattern and participates in the regulation of plant primary metabolism, and that this kinase confers ABA hypersensitivity during seedling growth.
Journal ArticleDOI
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation
Daniel J Gachotte,S. E. Sen,James A. Eckstein,Robert J. Barbuch,M. Krieger,B. D. Ray,Martin Bard +6 more
TL;DR: Surprisingly, when erg27 was grown on cholesterol- or ergosterol-supplemented media, the endogenous compounds that accumulated were noncyclic sterol intermediates, and there was little or no accumulation of lanosterol or 3-ketosterols.
Journal ArticleDOI
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis
TL;DR: It is demonstrated that erg26 mutants grown on various sterol and heme-supplemented media accumulate nonesterified carboxylic acid sterols such as 4beta-methyl-4alpha-carboxy-cholesta-8,24-dien-3beta-o l, the predicted substrates for the C-3 sterol dehydrogenase.
Journal ArticleDOI
Canola engineered with a microalgal polyketide synthase-like system produces oil enriched in docosahexaenoic acid
Terence A. Walsh,Scott Bevan,Daniel J Gachotte,Cory M Larsen,William Moskal,P A Owens Merlo,Lyudmila Sidorenko,Ronnie E Hampton,Stoltz Virginia,Dayakar Pareddy,Geny Anthony,Pudota B. Bhaskar,Pradeep Reddy Marri,Lauren Clark,Wei Chen,Patrick S Adu-Peasah,Steven Wensing,Ross Zirkle,James G. Metz,James G. Metz +19 more
TL;DR: Canola oil containing healthful long chain omega-3 polyunsaturated fatty acids is produced from plants engineered with an algal polyketide synthase-like enzyme system as discussed by the authors.