D
Daniel M. Brown
Researcher at Laboratory of Molecular Biology
Publications - 153
Citations - 3870
Daniel M. Brown is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Nucleoside & Hydroxylamine. The author has an hindex of 34, co-authored 149 publications receiving 3805 citations. Previous affiliations of Daniel M. Brown include Kettering University & Worcester Foundation for Biomedical Research.
Papers
More filters
Journal ArticleDOI
A new linkage for solid phase synthesis of oligodeoxyribonucleotides
Brian S. Sproat,Daniel M. Brown +1 more
TL;DR: An aryl diisocyanate has been used to attach an appropriately protected 2'-deoxyribonucleoside bearing a free 3'-hydroxyl group, to a long chain alkylamine controlled pore glass support via a urethane moiety, in a simple two step procedure.
Journal ArticleDOI
Organic chemistry of nucleic acids
Journal ArticleDOI
The Mechanism of Mutation Induction by a Hydrogen Bond Ambivalent, Bicyclic N4-oxy-2′-deoxycytidine in Escherichia coli
TL;DR: It is shown here that dP is a potent mutagen in Escherichia coli and Salmonella typhimurium and that the resulting triphosphate induces a high rate of mutagenesis through replicational errors.
Patent
Tricyclic base analogues
Daniel M. Brown,David Loakes,David R. Williams,Fergal Hill,Shiv Kumar,Satyam Nampalli,Mark Mcdougall,Alan Lewis Hamilton,Clifford Smith,Adrian Christopher Simmonds,William Jonathan Cummins,Patrick J. Finn +11 more
TL;DR: The structure of nucleoside analogues have been studied in this article, where Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic acid backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms.
Journal ArticleDOI
433. Some heterocyclic analogues of stilbenes
Daniel M. Brown,George A. R. Kon +1 more