D
Daniel M. Brown
Researcher at Laboratory of Molecular Biology
Publications - 153
Citations - 3870
Daniel M. Brown is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Nucleoside & Hydroxylamine. The author has an hindex of 34, co-authored 149 publications receiving 3805 citations. Previous affiliations of Daniel M. Brown include Kettering University & Worcester Foundation for Biomedical Research.
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Comparative mutagenicities of N6-methoxy-2,6-diaminopurine and N6-methoxyaminopurine 2′-deoxyribonucleosides and their 5′-triphosphates
TL;DR: The structure of the deoxyribonucleoside derived from N 6-methoxy-2, 6-diaminopurine (dK) was examined by NMR and the nucleoside proved to be a potent transition mutagen in Escherichia coli, in contrast to the closely related nucleosides derived from the analogue N6- methoxyaminopurines (dZ), which was only weakly mutagenic.
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Mutagenic analogues of cytosine: RNA polymerase template and substrate studies
G.R. Banks,G.R. Banks,Daniel M. Brown,Daniel M. Brown,D.G. Stereeter,D.G. Stereeter,L. Grossman,L. Grossman +7 more
TL;DR: Study of the substrate requirements for polynucleotide synthesis showed that with GTP poly rG was formed and that added ATP gave rise to poly (G,A) which, in the limit, had a base ratio approaching that of the template.
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The stability of oligodeoxyribonucleotide duplexes containing degenerate bases
TL;DR: Oligodeoxyribonucleotides containing N4-methoxycytosine (mo4C), N 4- methoxy-5-methylcytOSine (Mo4m5C) and other base-analogues were synthesised and used to compare the stabilities of duplexes containing mo4C.A and mo4M5C.G base pairs with those containing normal and mismatch pairs.
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Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA.
Luc Van Meervelt,Luc Van Meervelt,Madeleine H. Moore,Paul Kong Thoo Lin,Daniel M. Brown,Olga Kennard +5 more
TL;DR: In this paper, the structure of the base analogue N4-methoxycytosine (mo4C) has been determined by single-crystal X-ray diffraction techniques.
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Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-1 mapped by site-directed mutagenesis.
E. Jane Mitchell,Jonathan Karn,Daniel M. Brown,Andrew J. Newman,Ross Jakes,John Kendrick-Jones +5 more
TL;DR: Site-directed mutagenesis of the cloned subfragment-1 (S-1) region of the unc-54 gene, encoding the myosin heavy chain B (MHC B) from Caenorhabditis elegans, has been used to locate binding sites for the regulatory and essential light chains.