D
Daniel P. Szeto
Researcher at University of Washington
Publications - 22
Citations - 4058
Daniel P. Szeto is an academic researcher from University of Washington. The author has contributed to research in topics: Transcription factor & Zebrafish. The author has an hindex of 18, co-authored 22 publications receiving 3945 citations. Previous affiliations of Daniel P. Szeto include University of California, Berkeley & University of California, San Diego.
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Journal ArticleDOI
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
Chijen R. Lin,Chrissa Kioussi,Shawn M. O'Connell,Paola Briata,Daniel P. Szeto,Forrest Liu,Juan Carlos Izpisúa-Belmonte,Michael G. Rosenfeld +7 more
TL;DR: The phenotype of Pitx2 gene-deleted mice is described, characterized by defective body-wall closure, right pulmonary isomerism, altered cardiac position, arrest in turning and, subsequently, a block in the determination and proliferation events of anterior pituitary gland and tooth organogenesis.
Journal ArticleDOI
Multistep signaling requirements for pituitary organogenesis in vivo
Mathias Treier,Anatoli S. Gleiberman,Shawn M. O'Connell,Daniel P. Szeto,Jill A. McMahon,Andrew P. McMahon,Michael G. Rosenfeld +6 more
TL;DR: The molecular basis of generating diverse pituitary cell phenotypes from a common precursor is investigated, providing in vivo and in vitro evidence that their development involves three sequential phases of signaling events and the action of a gradient at an ectodermal boundary.
Journal ArticleDOI
Function of a Bacterial Activator Protein that Binds to Transcriptional Enhancers
TL;DR: The nitrogen regulatory (NtrC) protein of enteric bacteria, which binds to sites that have the properties of transcriptional enhancers, is known to activate transcription by a form of RNA polymerase that contains the NtrA protein (sigma 54) as sigma factor (referred to as s Sigma 54-holoenzyme).
Journal ArticleDOI
Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.
Daniel P. Szeto,Concepción Rodríguez-Esteban,Aimee K. Ryan,Shawn M. O'Connell,Forrest Liu,Chrissa Kioussi,Anatoli S. Gleiberman,Juan Carlos Izpisúa-Belmonte,Michael G. Rosenfeld +8 more
TL;DR: Pitx1 gene-deleted mice exhibit striking abnormalities in morphogenesis and growth of the hindlimb, resulting in a limb that exhibits structural changes in tibia and fibula as well as patterning alterations in patella and proximal tarsus, to more closely resemble the corresponding forelimb structures.
Journal ArticleDOI
Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient–Induced Determination of Pituitary Cell Types
Jeremy S. Dasen,Shawn M. O'Connell,Sarah E. Flynn,Mathias Treier,Anatoli S. Gleiberman,Daniel P. Szeto,Farideh Hooshmand,Aneel K. Aggarwal,Michael G. Rosenfeld +8 more
TL;DR: It is demonstrated that the appearance of four ventral pituitary cell types is mediated via the reciprocal interactions of two transcription factors, Pit1 and GATA2, which are epistatic to the remainder of the cell type-specific transcription programs and serve as the molecular memory of the transient signaling events.