S
Sarah E. Flynn
Researcher at University of California, San Diego
Publications - 8
Citations - 3891
Sarah E. Flynn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 8, co-authored 8 publications receiving 3832 citations. Previous affiliations of Sarah E. Flynn include Howard Hughes Medical Institute.
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Journal ArticleDOI
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.
Holly A. Ingraham,Ruoping Chen,Harry J. Mangalam,Harry P. Elsholtz,Sarah E. Flynn,Chijen R. Lin,Donna M. Simmons,Donna M. Simmons,Larry W. Swanson,Michael G. Rosenfeld +9 more
TL;DR: The structure of Pit-1 and its recognition elements suggests that metazoan tissue phenotype is controlled by a family of transcription factors that bind to related cis-active elements and contain several highly conserved domains.
Journal ArticleDOI
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
Mark W. Sornson,Wei Wu,Jeremy S. Dasen,Sarah E. Flynn,Deborah J. Norman,Shawn M. O'Connell,Ilya Gukovsky,Catherine Carrière,Aimee K. Ryan,Andrew P. Miller,Lin Zuo,Anatoli S. Gleiberman,Bogi Andersen,Wes G. Beamer,Michael G. Rosenfeld +14 more
TL;DR: The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1).
Journal ArticleDOI
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.
Eileen M. McInerney,David W. Rose,Sarah E. Flynn,Stefan Westin,Tina-Marie Mullen,Anna Krones,Juan Inostroza,Joseph Torchia,Robert T. Nolte,Nuria Assa-Munt,Michael V. Milburn,Christopher K. Glass,Michael G. Rosenfeld +12 more
TL;DR: Data suggest that the LXXLL-containing motifs have evolved to serve overlapping roles that are likely to permit both receptor-specific and ligand-specific assembly of a coactivator complex, and that these recognition motifs underlie the recruitment of coActivator complexes required for nuclear receptor function.
Journal ArticleDOI
Mutations in PROP1 cause familial combined pituitary hormone deficiency
Wei Wu,Joy D. Cogan,Roland Pfäffle,Jeremy S. Dasen,Herwig Frisch,Shawn M. O'Connell,Sarah E. Flynn,Milton R. Brown,Primus E. Mullis,John S. Parks,John A. Phillips,Michael G. Rosenfeld +11 more
TL;DR: The results identify a major cause of CPHD in humans and suggest a direct or indirect role for PROP1 in the ontogenesis of pituitary gonadotropes, as well as somatotrope, lactotropes and caudomedial thyrotropes.
Journal ArticleDOI
The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.
Holly A. Ingraham,Sarah E. Flynn,Jeffrey W. Voss,Vivian R. Albert,Michael S. Kapiloff,Laura Wilson,Michael G. Rosenfeld +6 more
TL;DR: Analysis of mutant Pit-1 proteins suggests that, while the POUHD is required and sufficient for low affinity DNA binding, the POUS domain is necessary for high affinity binding and accurate recognition of natural Pit- 1 response elements.