D
Daniele V.F. Tauriello
Researcher at Radboud University Nijmegen
Publications - 34
Citations - 4604
Daniele V.F. Tauriello is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Colorectal cancer & Medicine. The author has an hindex of 14, co-authored 20 publications receiving 3386 citations. Previous affiliations of Daniele V.F. Tauriello include Utrecht University.
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Journal ArticleDOI
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Daniele V.F. Tauriello,Sergio Palomo-Ponce,Diana Stork,Antonio Berenguer-Llergo,Jordi Badia-Ramentol,Mar Iglesias,Marta Sevillano,Sales Ibiza,Adrià Cañellas,Xavier Hernando-Momblona,Daniel Byrom,Joan A. Matarin,Alexandre Calon,Elisa I. Rivas,Angel R. Nebreda,Antoni Riera,Camille Stephan-Otto Attolini,Eduard Batlle +17 more
TL;DR: Increased TGFβ in the tumour microenvironment represents a primary mechanism of immune evasion that promotes T-cell exclusion and blocks acquisition of the TH1-effector phenotype, and immunotherapies directed against TGF β signalling may have broad applications in treating patients with advanced colorectal cancer.
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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
Alexandre Calon,Elisa Espinet,Sergio Palomo-Ponce,Daniele V.F. Tauriello,Mar Iglesias,María Virtudes Céspedes,Marta Sevillano,Cristina Nadal,Peter Jung,Xiang Zhang,Daniel Byrom,Antoni Riera,David Rossell,Ramon Mangues,Joan Massagué,Joan Massagué,Elena Sancho,Eduard Batlle +17 more
TL;DR: A prometastatic program induced by TGF-β in the microenvironment that associates with a high risk of CRC relapse upon treatment is unveiled and could be exploited to improve the diagnosis and treatment of CRC.
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Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Alexandre Calon,Enza Lonardo,Antonio Berenguer-Llergo,Elisa Espinet,Xavier Hernando-Momblona,Mar Iglesias,Marta Sevillano,Sergio Palomo-Ponce,Daniele V.F. Tauriello,Daniel Byrom,Carme Cortina,Clara Morral,Carles Barceló,Sébastien Tosi,Antoni Riera,Camille Stephan-Otto Attolini,David Rossell,Elena Sancho,Eduard Batlle +18 more
TL;DR: It is shown that the use of TGF-β signaling inhibitors to block the cross-talk between cancer cells and the microenvironment halts disease progression, and all poor-prognosis CRC subtypes share a gene program induced by T GF-β in tumor stromal cells.
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Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Henner F. Farin,Ingrid Jordens,Mohammed H. Mosa,Mohammed H. Mosa,Onur Basak,Jeroen Korving,Daniele V.F. Tauriello,Karin de Punder,Stephane Angers,Peter J. Peters,Madelon M. Maurice,Hans Clevers +11 more
TL;DR: It is concluded that stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and ‘plasma membrane dilution’ through cell division shape the epithelial Wnt3 gradient.
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TGF-beta in CAF-mediated tumor growth and metastasis
TL;DR: Current evidence on the emerging mechanisms involving TGF-beta in CAF-mediated cancer progression are examined, and their potential as therapeutic targets are discussed.