C
Cristina Nadal
Researcher at University of Barcelona
Publications - 23
Citations - 4830
Cristina Nadal is an academic researcher from University of Barcelona. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 12, co-authored 22 publications receiving 4300 citations. Previous affiliations of Cristina Nadal include Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Genes that mediate breast cancer metastasis to the brain
Paula D. Bos,Xiang Zhang,Cristina Nadal,Weiping Shu,Roger R. Gomis,Don X. Nguyen,Andy J. Minn,Marc J. van de Vijver,William L. Gerald,John A. Foekens,Joan Massagué,Joan Massagué +11 more
TL;DR: It is shown that breast cancer metastasis to the brain involves mediators of extravasation through non-fenestrated capillaries, complemented by specific enhancers of blood–brain barrier crossing and brain colonization.
Journal ArticleDOI
TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
David Padua,Xiang Zhang,Qiongqing Wang,Cristina Nadal,William L. Gerald,Roger R. Gomis,Joan Massagué +6 more
TL;DR: It is shown that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cells for metastasis to the lungs, central to this process is the induction of angiopoietin-like 4 (ANGPTL4) by TGF beta via the Smad signaling pathway.
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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
Alexandre Calon,Elisa Espinet,Sergio Palomo-Ponce,Daniele V.F. Tauriello,Mar Iglesias,María Virtudes Céspedes,Marta Sevillano,Cristina Nadal,Peter Jung,Xiang Zhang,Daniel Byrom,Antoni Riera,David Rossell,Ramon Mangues,Joan Massagué,Joan Massagué,Elena Sancho,Eduard Batlle +17 more
TL;DR: A prometastatic program induced by TGF-β in the microenvironment that associates with a high risk of CRC relapse upon treatment is unveiled and could be exploited to improve the diagnosis and treatment of CRC.
Journal ArticleDOI
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gaorav P. Gupta,Don X. Nguyen,Anne C. Chiang,Paula D. Bos,Juliet Y. Kim,Cristina Nadal,Roger R. Gomis,Katia Manova-Todorova,Joan Massagué +8 more
TL;DR: Findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations.
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C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells
TL;DR: It is suggested that C/EBPbeta plays a key role in the coordination of TGFbeta cytostatic gene responses, and its malfunction may trigger evasion of these responses in breast cancer.