David J. Simon

TL;DR: iDISCO enables facile volume imaging of immunolabeled structures in complex tissues and reveals unexpected variability in number of apoptotic neurons within individual sensory ganglia despite tight control of total number in all ganglia.

TL;DR: Using traumatic injury as a model, this work systematically investigates mitogen-activated protein kinase (MAPK) families and delineates a MAPK cascade that represents the early degenerative response to axonal injury, revealing a regulatory mechanism that integrates distinct signals to instruct pathological axon degeneration.

TL;DR: It is proposed that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function, suggesting that MEF-2 activity in muscles controls a retrograde signal.

TL;DR: In vitro, it is shown that genetic deletion of Caspase-3 is fully protective against sensory axon degeneration initiated by trophic factor withdrawal, but not injury-induced Wallerian degeneration, and a biochemical cascade from prosurvival Bcl2 family regulators to Caspasase-9, then Caspases-3, and then Cazase-6 is defined.

TL;DR: It is demonstrated that this membrane-associated periodic skeleton (MPS) is present in a broad range of neuronal cell types cultured from the central and peripheral nervous systems of rodents, and that spectrin is capable of adopting a similar periodic organization in neurons of a variety of animal species.