Lilian Phu

TL;DR: In this paper, Parkin ubiquitinates and tags damaged mitochondria for clearance, and USP30, a deubiquitinase localized to mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin.

TL;DR: Serum-regulated upstream vesicular transport events leading to centrosomal Rab8 activation and ciliary membrane formation are described, and it is determined that the transport protein particle (TRAPP) II complex associates with the Rabin8 NH2-terminal domain and show that TRAPP II subunits colocalize with centrosomes and are required for Rabin 8 preciliary targeting and ciliogenesis.

TL;DR: It is shown that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS), and Knockin mice expressing B AP1 with a 3xFlag tag revealed that BAP1 interacts with host cell factor–1, O-linked N-acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL

TL;DR: A K11 linkage-specific antibody is engineered and used to demonstrate that K11 chains are highly upregulated in mitotic human cells precisely when substrates of the ubiquitin ligase anaphase-promoting complex (APC/C) are degraded.

TL;DR: It is demonstrated that c‐IAP1 and UbcH5 family promote K11‐linked polyubiquitination of receptor‐interacting protein 1 (RIP1) in vitro and in vivo and it is shown that TNFα‐stimulated NF‐κB activation involves endogenous K 11‐linked ubiquitinations of RIP1 within the TNFR1 signalling complex that is c-IAP 1 and Ub cH5 dependent.