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Darby J. S. Thompson
Researcher at Simon Fraser University
Publications - 75
Citations - 3703
Darby J. S. Thompson is an academic researcher from Simon Fraser University. The author has contributed to research in topics: Prostatectomy & Prostate cancer. The author has an hindex of 25, co-authored 73 publications receiving 3293 citations. Previous affiliations of Darby J. S. Thompson include National Institutes of Health.
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Journal ArticleDOI
Ciliary neurotrophic factor (CNTF) for human retinal degeneration : Phase I trial of CNTF delivered by encapsulated cell intraocular implants
Paul A. Sieving,Rafael C. Caruso,Weng Tao,Hanna R. Coleman,Darby J. S. Thompson,Keri R. Fullmer,Ronald A. Bush +6 more
TL;DR: This Phase I trial indicated that CNTF is safe for the human retina even with severely compromised photoreceptors, and the approach to delivering therapeutic proteins to degenerating retinas using encapsulated cell implants may have application beyond disease caused by genetic mutations.
Journal Article
Conjunctival T-Cell Subpopulations in Sjogren's and Non-Sjogren's Patients with Dry Eye
Michael E. Stern,Jianping Gao,Tammy A. Schwalb,Mylinh Ngo,David D. Tieu,Chi-Chao Chan,Brenda L. Reis,Scott M. Whitcup,Darby J. S. Thompson,Janine A. Smith +9 more
TL;DR: The authors' findings indicate that patients with Sjögren's syndrome keratoconjunctivitis sicca or NS-KCS have conjunctival inflammation manifested by inflammatory cell infiltrates and upregulation of expression in markers of immune activation.
Journal ArticleDOI
A field trial to assess a blood-Stage malaria vaccine
Mahamadou A. Thera,Ogobara K. Doumbo,Drissa Coulibaly,Matthew B. Laurens,Amed Ouattara,Abdoulaye K. Kone,Ando B. Guindo,Karim Traore,Idrissa Traore,Bourema Kouriba,Dapa A. Diallo,Issa Diarra,Modibo Daou,Amagana Dolo,Youssouf Tolo,Mahamadou S. Sissoko,Amadou Niangaly,Mady Sissoko,Shannon Takala-Harrison,Kirsten E. Lyke,Yukun Wu,William C. Blackwelder,Olivier Godeaux,Johan Vekemans,Marie-Claude Dubois,W. Ripley Ballou,Joe Cohen,Darby J. S. Thompson,Tina J. T. Dube,Lorraine Soisson,Carter L. Diggs,Brent House,David E. Lanar,Sheetij Dutta,D. Gray Heppner,Christopher V. Plowe +35 more
TL;DR: The malaria vaccine did not provide significant protection against clinical malaria, but on the basis of secondary results, it may have strain-specific efficacy.
Journal ArticleDOI
Validation of a Genomic Classifier that Predicts Metastasis Following Radical Prostatectomy in an At Risk Patient Population
R. Jeffrey Karnes,Eric J. Bergstralh,Elai Davicioni,Mercedeh Ghadessi,Christine Buerki,Anirban P. Mitra,Anamaria Crisan,Nicholas Erho,Ismael A. Vergara,Lucia L. Lam,Rachel Carlson,Darby J. S. Thompson,Zaid Haddad,Benedikt Zimmermann,Thomas Sierocinski,Timothy J. Triche,Thomas M. Kollmeyer,Karla V. Ballman,Peter C. Black,George G. Klee,Robert B. Jenkins +20 more
TL;DR: Results indicate that genomic information from the primary tumor can identify patients with adverse pathological features who are most at risk for metastasis and potentially lethal prostate cancer.
Journal ArticleDOI
A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis.
Janine A. Smith,Darby J. S. Thompson,Scott M. Whitcup,Eric B. Suhler,Grace Clarke,Susan F Smith,Michael R. Robinson,Jonghyeon Kim,Karyl S. Barron +8 more
TL;DR: There was no apparent difference in the anterior segment inflammation between patients treated with etanercept and placebo and the stringent criteria used to measure ophthalmic success of treatment and the small patient population limit the implications of the findings.