A
Abdoulaye K. Kone
Researcher at University of the Sciences
Publications - 75
Citations - 3581
Abdoulaye K. Kone is an academic researcher from University of the Sciences. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 26, co-authored 68 publications receiving 3158 citations. Previous affiliations of Abdoulaye K. Kone include National Institutes of Health & University of Maryland, Baltimore.
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Journal ArticleDOI
Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1β), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls
Kirsten E. Lyke,R. Burges,Yacouba Cissoko,Lansana Sangaré,M. Dao,Issa Diarra,Abdoulaye K. Kone,R. Harley,Christopher V. Plowe,Ogobara K. Doumbo,Marcelo B. Sztein +10 more
TL;DR: The complex relationships between inflammatory cytokines and disease in P. falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, are illustrated.
Journal ArticleDOI
Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
J. Alexandra Rowe,Ian Handel,Mahamadou A. Thera,Anne-Marie Deans,Kirsten E. Lyke,Abdoulaye K. Kone,Dapa A. Diallo,Ahmed Raza,Oscar Kai,Kevin Marsh,Christopher V. Plowe,Ogobara K. Doumbo,Joann M. Moulds +12 more
TL;DR: In a matched case-control study of 567 Malian children, the authors found that group O was present in only 21% of severe malaria cases compared with 44-45% of uncomplicated malaria controls and healthy controls.
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A field trial to assess a blood-Stage malaria vaccine
Mahamadou A. Thera,Ogobara K. Doumbo,Drissa Coulibaly,Matthew B. Laurens,Amed Ouattara,Abdoulaye K. Kone,Ando B. Guindo,Karim Traore,Idrissa Traore,Bourema Kouriba,Dapa A. Diallo,Issa Diarra,Modibo Daou,Amagana Dolo,Youssouf Tolo,Mahamadou S. Sissoko,Amadou Niangaly,Mady Sissoko,Shannon Takala-Harrison,Kirsten E. Lyke,Yukun Wu,William C. Blackwelder,Olivier Godeaux,Johan Vekemans,Marie-Claude Dubois,W. Ripley Ballou,Joe Cohen,Darby J. S. Thompson,Tina J. T. Dube,Lorraine Soisson,Carter L. Diggs,Brent House,David E. Lanar,Sheetij Dutta,D. Gray Heppner,Christopher V. Plowe +35 more
TL;DR: The malaria vaccine did not provide significant protection against clinical malaria, but on the basis of secondary results, it may have strain-specific efficacy.
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Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S
Aarti Agarwal,Aarti Agarwal,Aldiouma Guindo,Aldiouma Guindo,Yacouba Cissoko,Yacouba Cissoko,James G. Taylor,James G. Taylor,Drissa Coulibaly,Drissa Coulibaly,Abdoulaye K. Kone,Abdoulaye K. Kone,Kassoum Kayentao,Kassoum Kayentao,Abdoulaye A. Djimde,Abdoulaye A. Djimde,Christopher V. Plowe,Christopher V. Plowe,Ogobara K. Doumbo,Ogobara K. Doumbo,Thomas E. Wellems,Thomas E. Wellems,Dapa A. Diallo,Dapa A. Diallo +23 more
TL;DR: It is suggested that HbC does not protect against infection or uncomplicated malaria but can protect against severe malaria in the Dogon population of Bandiagara, Mali, and the protective effect associated with HBC may be greater than that of HbS in this population.
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Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
Helen M. Kyriacou,Graham N. Stone,Richard Challis,Arif Ahmed Raza,Kirsten E. Lyke,Mahamadou A. Thera,Abdoulaye K. Kone,Ogobara K. Doumbo,Christopher V. Plowe,J. Alexandra Rowe +9 more
TL;DR: It is suggested that var genes with DBLα1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes in other groups promote less virulent malaria infections.