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Daria Y. Alakhova
Researcher at University of North Carolina at Chapel Hill
Publications - 19
Citations - 2991
Daria Y. Alakhova is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cancer & P-glycoprotein. The author has an hindex of 12, co-authored 19 publications receiving 2635 citations. Previous affiliations of Daria Y. Alakhova include University of Nebraska Medical Center & University of Nebraska–Lincoln.
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Journal ArticleDOI
Endocytosis of Nanomedicines
TL;DR: This review describes the current experimental tools to study endocytosis of nanomedicines and provides specific examples from recent literature and the authors' own work on endocyTosis of Nanomedicine.
Journal ArticleDOI
Pluronics and MDR reversal: an update.
TL;DR: How MDR can be overcome by a simple yet effective approach of using amphiphilic block copolymers is described.
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Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles
Robert Luxenhofer,Robert Luxenhofer,Robert Luxenhofer,Gaurav Sahay,Gaurav Sahay,Anita Schulz,Daria Y. Alakhova,Tatiana K. Bronich,Rainer Jordan,Alexander V. Kabanov +9 more
TL;DR: The relative cytotoxicity of POx is tested and it is confirmed that these polymers are typically not cytotoxic even at high concentrations, and structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini are reported.
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A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity.
Zhijian He,Xiaomeng Wan,Anita Schulz,Herdis Bludau,Marina A. Dobrovolskaia,Stephan T. Stern,Stephanie A. Montgomery,Hong Yuan,Zibo Li,Daria Y. Alakhova,Marina Sokolsky,David B. Darr,Charles M. Perou,Rainer Jordan,Robert Luxenhofer,Alexander V. Kabanov,Alexander V. Kabanov +16 more
TL;DR: In this paper, a nano-formulation of paclitaxel (PTX) is presented, which is characterized by a facile preparation, extraordinary high drug loading of 50% wt. and PTX solubility of up to 45g/L, excellent shelf stability and controllable sub-100nm size.
Journal ArticleDOI
Differential metabolic responses to pluronic in MDR and non-MDR cells: A novel pathway for chemosensitization of drug resistant cancers
Daria Y. Alakhova,Nataliya Y. Rapoport,Elena V. Batrakova,Alexander A. Timoshin,Shu Li,David G. Nicholls,Valery Yu Alakhov,Alexander V. Kabanov,Alexander V. Kabanov +8 more
TL;DR: It is demonstrated that Pluronic rapidly (15min) translocates into MDR cells and co-localizes with the mitochondria, and its effects eventually enhance drug-induced apoptosis and contribute to potent chemosensitization of MDR tumors by pluronic.