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Philip N. Howles
Researcher at University of Cincinnati
Publications - 45
Citations - 3405
Philip N. Howles is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Cholesterol & Reverse cholesterol transport. The author has an hindex of 24, co-authored 45 publications receiving 3207 citations. Previous affiliations of Philip N. Howles include Children's Hospital Oakland Research Institute & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Transforming growth factor-β3 is required for secondary palate fusion
Gabriele Proetzel,Sharon A. Pawlowski,Michael V. Wiles,Moying Yin,Gregory P. Boivin,Philip N. Howles,Jixang Ding,Mark W. J. Ferguson,Thomas Doetschman +8 more
TL;DR: This result demonstrates that TGF–β3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
Journal ArticleDOI
The central melanocortin system directly controls peripheral lipid metabolism
Rubén Nogueiras,Petra Wiedmer,Diego Perez-Tilve,Christelle Veyrat-Durebex,Julia M. Keogh,Gregory M. Sutton,Paul T. Pfluger,Tamara R. Castañeda,Susanne Neschen,Susanna M. Hofmann,Philip N. Howles,Donald A. Morgan,Stephen C. Benoit,Ildiko Szanto,Brigitte Schrott,Annette Schürmann,Hans-Georg Joost,Craig Hammond,David Y. Hui,Stephen C. Woods,Kamal Rahmouni,Andrew A. Butler,I. Sadaf Farooqi,Stephen O'Rahilly,Françoise Rohner-Jeanrenaud,Matthias H. Tschöp +25 more
TL;DR: Pharmacological inhibition of melanocortin receptors in rats and genetic disruption of Mc4r in mice directly and potently promoted lipid uptake, triglyceride synthesis, and fat accumulation in white adipose tissue (WAT), while increased CNS-Mcr signaling triggered lipid mobilization.
Journal ArticleDOI
Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis.
David Y. Hui,Philip N. Howles +1 more
TL;DR: This enzyme, which has a wide substrate reactivity and diffuse anatomic distribution, may have multiple functions in lipid and lipoprotein metabolism, and atherosclerosis.
Journal ArticleDOI
Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.
TL;DR: The data indicate that mouse embryoid bodies transcribe the appropriate tissue- and developmental stage-specific myosin heavy chain genes and therefore serve as a model system for studying early cardiogenic processes at the molecular level.
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Dietary Free and Esterified Cholesterol Absorption in Cholesterol Esterase (Bile Salt-stimulated Lipase) Gene-targeted Mice
TL;DR: The results indicate that cholesterol esterase is responsible for mediating intestinal absorption of cholesteryl esters but does not play a primary role in free cholesterol absorption.