D
Dylan J. Taatjes
Researcher at University of Colorado Boulder
Publications - 98
Citations - 11006
Dylan J. Taatjes is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: RNA polymerase II & Mediator. The author has an hindex of 42, co-authored 88 publications receiving 8956 citations. Previous affiliations of Dylan J. Taatjes include Howard Hughes Medical Institute & University of California, Berkeley.
Papers
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Mediator and cohesin connect gene expression and chromatin architecture
Michael H. Kagey,Jamie J. Newman,Steve Bilodeau,Ye Zhan,David A. Orlando,Nynke L. van Berkum,Christopher C. Ebmeier,Jesse Goossens,Peter B. Rahl,Stuart S. Levine,Dylan J. Taatjes,Job Dekker,Richard A. Young +12 more
TL;DR: It is reported that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells.
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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Ann Boija,Isaac A. Klein,Benjamin R. Sabari,Alessandra Dall’Agnese,Eliot L. Coffey,Alicia V. Zamudio,Charles H. Li,Krishna Shrinivas,John C. Manteiga,Nancy M. Hannett,Brian J. Abraham,Lena K. Afeyan,Yang Eric Guo,Jenna K. Rimel,Charli B. Fant,Jurian Schuijers,Tong Ihn Lee,Dylan J. Taatjes,Richard A. Young +18 more
TL;DR: It is reported that diverse ADs form phase- separated condensates with the Mediator coactivator, suggesting that diverse TFs can interact with Mediator through the phase-separating capacity of their ADs and that formation of condensate with Mediation is involved in gene activation.
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Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
Fan Lai,Ulf Andersson Ørom,Matteo Cesaroni,Malte Beringer,Dylan J. Taatjes,Gerd A. Blobel,Ramin Shiekhattar +6 more
TL;DR: In this paper, depletion of the components of the co-activator complex, Mediator, specifically and potently diminished the ncRNA-induced activation of transcription in a heterologous reporter assay using human HEK293 cells.
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The Mediator complex: a central integrator of transcription
TL;DR: Although Mediator exists in all eukaryotes, a variety of Mediator functions seem to be specific to metazoans, which is indicative of more diverse regulatory requirements.
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Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Yang Eric Guo,John C. Manteiga,Jonathan E. Henninger,Benjamin R. Sabari,Alessandra Dall’Agnese,Nancy M. Hannett,Jan-Hendrik Spille,Jan-Hendrik Spille,Lena K. Afeyan,Alicia V. Zamudio,Krishna Shrinivas,Brian J. Abraham,Brian J. Abraham,Ann Boija,Tim-Michael Decker,Jenna K. Rimel,Charli B. Fant,Tong Ihn Lee,Ibrahim I Cisse,Phillip A. Sharp,Dylan J. Taatjes,Richard A. Young +21 more
TL;DR: In this paper, the authors investigated whether the phosphorylation of the C-terminal domain of the RNA polymerase II (PolII) C-interaction subunit regulates the incorporation of Pol II into phase-separated condensates that are associated with transcription initiation and splicing.