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Uwe Ohler

Researcher at Max Delbrück Center for Molecular Medicine

Publications -  184
Citations -  14912

Uwe Ohler is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 56, co-authored 162 publications receiving 12111 citations. Previous affiliations of Uwe Ohler include University of California, Berkeley & Humboldt State University.

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A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns

TL;DR: Methods that combine microarray expression profiles of a high-resolution set of developmental time points within a single Arabidopsis root and a comprehensive map of nearly all root cell types demonstrate transcriptionally rich and complex programs that define Arabidrosis root development in both space and time.
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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Jonas Schulte-Schrepping, +137 more
- 17 Sep 2020 - 
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
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FMRP targets distinct mRNA sequence elements to regulate protein expression

TL;DR: The discovery of distinct RNA-recognition elements that correspond to the two independent RNA-binding domains of FMRP and the discovery that these targets are also dysregulated in Fmr1−/− mouse ovaries showing signs of premature follicular overdevelopment indicate that FMRp targets share signalling pathways across different cellular contexts.
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Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

TL;DR: Comparison of the spatial patterns surrounding HuR and miRNA binding sites provided functional evidence for HuR-dependent antagonism of proximal miRNA-mediated repression and it is concluded that HuR coordinates gene expression outcomes at multiple interconnected steps of RNA processing.
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A viral microRNA functions as an orthologue of cellular miR-155

TL;DR: It is reported that the miR-K12-11 miRNA encoded by Kaposi’s-sarcoma-associated herpes virus shows significant homology to cellular mi-155, including the entire miRNA ‘seed’ region.