U
Uwe Ohler
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 184
Citations - 14912
Uwe Ohler is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 56, co-authored 162 publications receiving 12111 citations. Previous affiliations of Uwe Ohler include University of California, Berkeley & Humboldt State University.
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Journal ArticleDOI
A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns
Siobhan M. Brady,David A. Orlando,Ji-Young Lee,Jean Y. J. Wang,Jeremy D. Koch,José R. Dinneny,Daniel L. Mace,Uwe Ohler,Philip N. Benfey +8 more
TL;DR: Methods that combine microarray expression profiles of a high-resolution set of developmental time points within a single Arabidopsis root and a comprehensive map of nearly all root cell types demonstrate transcriptionally rich and complex programs that define Arabidrosis root development in both space and time.
Journal ArticleDOI
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Jonas Schulte-Schrepping,Nico Reusch,Daniela Paclik,Kevin Baßler,Stephan Schlickeiser,Bowen Zhang,Benjamin Krämer,Tobias Krammer,Sophia Brumhard,Lorenzo Bonaguro,Elena De Domenico,Daniel Wendisch,Martin Grasshoff,Theodore S. Kapellos,Michael Beckstette,Tal Pecht,Adem Saglam,Oliver Dietrich,Henrik E. Mei,Axel Schulz,Claudia Conrad,Désirée Kunkel,Ehsan Vafadarnejad,Cheng-Jian Xu,Cheng-Jian Xu,Arik Horne,Miriam Herbert,Anna Drews,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Holger Müller-Redetzky,Katrin-Moira Heim,Felix Machleidt,Alexander Uhrig,Laure Bosquillon de Jarcy,Linda Jürgens,Miriam Stegemann,Christoph R. Glösenkamp,Hans-Dieter Volk,Christine Goffinet,Markus Landthaler,Emanuel Wyler,Philipp Georg,Maria Schneider,Chantip Dang-Heine,Nick Neuwinger,Kai Kappert,Rudolf Tauber,Victor M. Corman,Jan Raabe,Kim Melanie Kaiser,Michael To Vinh,Gereon Rieke,Christian Meisel,Thomas Ulas,Matthias Becker,Robert Geffers,Martin Witzenrath,Christian Drosten,Norbert Suttorp,Christof von Kalle,Florian Kurth,Florian Kurth,Florian Kurth,Kristian Händler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner,Anna C. Aschenbrenner,Yang Li,Yang Li,Jacob Nattermann,Birgit Sawitzki,Antoine-Emmanuel Saliba,Leif E. Sander,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colomé-Tatché,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Nikolaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Philip Rosenstiel,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Fabian J. Theis,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +137 more
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
Journal ArticleDOI
FMRP targets distinct mRNA sequence elements to regulate protein expression
Manuel Ascano,Neelanjan Mukherjee,Pradeep Bandaru,Jason B. Miller,Jeffrey Nusbaum,David L. Corcoran,Christine Langlois,Mathias Munschauer,Scott Dewell,Markus Hafner,Zev Williams,Zev Williams,Uwe Ohler,Thomas Tuschl +13 more
TL;DR: The discovery of distinct RNA-recognition elements that correspond to the two independent RNA-binding domains of FMRP and the discovery that these targets are also dysregulated in Fmr1−/− mouse ovaries showing signs of premature follicular overdevelopment indicate that FMRp targets share signalling pathways across different cellular contexts.
Journal ArticleDOI
Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
Neelanjan Mukherjee,David L. Corcoran,Jeffrey Nusbaum,Jeffrey Nusbaum,David W. Reid,Stoyan Georgiev,Markus Hafner,Markus Hafner,Manuel Ascano,Manuel Ascano,Thomas Tuschl,Thomas Tuschl,Uwe Ohler,Jack D. Keene +13 more
TL;DR: Comparison of the spatial patterns surrounding HuR and miRNA binding sites provided functional evidence for HuR-dependent antagonism of proximal miRNA-mediated repression and it is concluded that HuR coordinates gene expression outcomes at multiple interconnected steps of RNA processing.
Journal ArticleDOI
A viral microRNA functions as an orthologue of cellular miR-155
Eva Gottwein,Neelanjan Mukherjee,Christoph Sachse,Corina Frenzel,William H. Majoros,Jen-Tsan Chi,Ravi Braich,Muthiah Manoharan,Jürgen Soutschek,Uwe Ohler,Bryan R. Cullen +10 more
TL;DR: It is reported that the miR-K12-11 miRNA encoded by Kaposi’s-sarcoma-associated herpes virus shows significant homology to cellular mi-155, including the entire miRNA ‘seed’ region.