D
David C. Montefiori
Researcher at Duke University
Publications - 995
Citations - 79717
David C. Montefiori is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 129, co-authored 920 publications receiving 70049 citations. Previous affiliations of David C. Montefiori include Emory University & University of California, Davis.
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Optimized Mucosal MVA Prime/ Soluble gp120 Boost Vaccination Regimen Induces Similar Antibody Responses as an Intramuscular Regimen
Dorothy I. Jones,Justin Pollara,Brandi T. Johnson-Weaver,Celia C. LaBranche,David C. Montefiori,David J. Pickup,Sallie R. Permar,Soman N. Abraham,Massimo Maddaloni,David W. Pascual,Herman F. Staats +10 more
TL;DR: Mucosal vaccination is proposed as a method of immunization able to induce protection against mucosal pathogens that is superior to protection provided by parenteral immunization.
Journal ArticleDOI
Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants.
Mingkui Zhou,Michael Humbert,Muhammad Mukhtar,Muhammad Mukhtar,Hanna B. Scinto,Hanna B. Scinto,Hemant K. Vyas,Hemant K. Vyas,Samir K. Lakhashe,Samir K. Lakhashe,Siddappa N. Byrareddy,Gregor Maurer,Gregor Maurer,Swati Thorat,Joshua Owuor,Zhao Lai,Yi Chen,Anthony Griffiths,Agnès Laurence Chenine,Sanjeev Gumber,Francois Villinger,Francois Villinger,David C. Montefiori,Ruth M. Ruprecht +23 more
TL;DR: Next-generation sequencing of early- and late-passage SHIV-A strains identified mutations that arose due to “fitness” virus optimization in the former and mutations exhibiting signatures typical for adaptive host immunity in the latter.
Journal ArticleDOI
Broadly Neutralizing Antibody Responses in a Subset of HIV-1-Infected Individuals in Chennai, India: Potential Avenues for Vaccine Design
Syed Iqbal Hussain,Nandagopal Panneerselvam,Suniti Solomon,Sunil S. Solomon,Sunil S. Solomon,Kaavya Adam,Ezhilarasi Chandrasekaran,David C. Montefiori,Balakrishnan Pachamuthu +8 more
TL;DR: High titers of HIV-1 cross-neutralizing activity were observed in the sera from a subset of HIV -1-infected individuals in Chennai, India, which may facilitate the discovery of an effective vaccine immunogen.