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David C. Montefiori
Researcher at Duke University
Publications - 995
Citations - 79717
David C. Montefiori is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 129, co-authored 920 publications receiving 70049 citations. Previous affiliations of David C. Montefiori include Emory University & University of California, Davis.
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Journal Article
Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys.
TL;DR: The results indicate that infection with SIVmac239delta3 causes disease in infant macaques despite their mounting of antiviral humoral immune responses comparable to those of adults.
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Evidence that Antibody-Mediated Neutralization of Human Immunodeficiency Virus Type 1 by Sera from Infected Individuals Is Independent of Coreceptor Usage
David C. Montefiori,Ronald G. Collman,Timothy R. Fouts,Ji Ying Zhou,Miroslawa Bilska,James A. Hoxie,John P. Moore,Dani P. Bolognesi +7 more
TL;DR: The results indicate that the ability of HIV-1 to be neutralized by sera from infected individuals depends on factors other than coreceptor usage.
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Evidence That Mannosyl Residues Are Involved in Human Immunodeficiency Virus Type 1 (HIV-1) Pathogenesis
TL;DR: It appears that at least some N-glycosylation sites are complex-type glycoproteins but regions external to the (GlcNAc)2(Man)3 "core" pentasaccharide region are not required for HIV infectivity.
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Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination.
Matthew J. Gorman,Nita Patel,Mimi Guebre-Xabier,Alex Lee Zhu,Alex Lee Zhu,Caroline Atyeo,Krista M. Pullen,Carolin Loos,Carolin Loos,Yenny Goez-Gazi,Ricardo Carrion,Jing-Hui Tian,Dansu Yuan,Kathryn Bowman,Bin Zhou,Sonia Maciejewski,Marisa McGrath,James Logue,Matthew B. Frieman,David C. Montefiori,Colin Mann,Sharon L. Schendel,Fatima Amanat,Florian Krammer,Erica Ollmann Saphire,Douglas A. Lauffenburger,Ann M. Greene,Alyse D. Portnoff,Michael J. Massare,Larry Ellingsworth,Gregory M. Glenn,Gale Smith,Galit Alter +32 more
TL;DR: In this paper, the authors profiled the humoral immune response in a cohort of non-human primates immunized with a recombinant SARS-CoV-2 spike glycoprotein (NVX CoV2373) at two doses, administered as a single or two-dose regimen.
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In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.
Patricia N. Fultz,Patricia J. Vance,Michael J. Endres,Binli Tao,Jeffrey D. Dvorin,Ian C. Davis,Jeffrey D. Lifson,David C. Montefiori,Mark Marsh,Michael H. Malim,James A. Hoxie +10 more
TL;DR: It is shown that mutation of a highly conserved tyrosine (Tyr)-containing motif (Yxxφ) in the envelope glycoprotein (Env) cytoplasmic tail (amino acids YRPV at positions 721 to 724) can profoundly reduce the in vivo pathogenicity of SIVmac239.