D
David C. Montefiori
Researcher at Duke University
Publications - 995
Citations - 79717
David C. Montefiori is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 129, co-authored 920 publications receiving 70049 citations. Previous affiliations of David C. Montefiori include Emory University & University of California, Davis.
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Journal ArticleDOI
Vaccine-induced neutralizing antibodies directed in part to the simian immunodeficiency virus (SIV) V2 domain were unable to protect rhesus monkeys from SIV experimental challenge.
K Schlienger,David C. Montefiori,Maryline Mancini,Y Rivière,Pierre Tiollais,Marie-Louise Michel +5 more
TL;DR: Despite having consistent SIV-neutralizing antibody titers, animals were not protected against homologous challenge with BK28, the molecular clone of SIVmac251, suggesting that neutralizing antibodies directed to SIV envelope gp140 and especially to the V2 domain were unable on their own to protect against SIV challenge.
Journal ArticleDOI
Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.
David R. Martinez,David R. Martinez,Joshua J. Tu,Amit Kumar,Jesse F. Mangold,Riley J. Mangan,Ria Goswami,Elena E. Giorgi,Jui-Lin Chen,Jui-Lin Chen,Michael Mengual,Ayooluwa O. Douglas,Holly Heimsath,Kevin O. Saunders,Kevin O. Saunders,Nathan I. Nicely,Joshua Eudailey,Giovanna Hernandez,Papa K Morgan-Asiedu,Kevin Wiehe,Barton F. Haynes,Barton F. Haynes,M. Anthony Moody,M. Anthony Moody,Celia C. LaBranche,David C. Montefiori,David C. Montefiori,Feng Gao,Sallie R. Permar,Sallie R. Permar +29 more
TL;DR: Maternal-plasma broadly neutralizing antibody (bNAb) responses can select for T/F viruses that initiate infection in infants and have important implications for bNAb-eliciting vaccines and passively administered bNAbs in the setting of MTCT.
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Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study
Catherine Cosgrove,Charles J.N. Lacey,Alethea Cope,Angela Bartolf,G Morris,Celine Yan,Susan Baden,Tom Cole,Darrick Carter,Elizabeth Brodnicki,Xiaoying Shen,Sarah Joseph,Stephen C. DeRosa,Lili Peng,Xuesong Yu,Guido Ferrari,Mike S. Seaman,David C. Montefiori,Nicole Frahm,Georgia D. Tomaras,Wolfgang Stöhr,Sheena McCormack,Robin J. Shattock +22 more
TL;DR: Data show that parenteral immunization elicits systemic and mucosal antibodies in women and Interestingly IN immunization was an effective prime for IM boost, while IVAG administration had no detectable impact on systemic or mucosal responses despite IM priming.
Journal ArticleDOI
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
Jordan R. Willis,Gopal Sapparapu,Sasha Murrell,Jean-Philippe Julien,Vidisha Singh,Hannah King,Yan Xia,Jennifer A. Pickens,Celia C. LaBranche,James C. Slaughter,David C. Montefiori,Ian A. Wilson,Jens Meiler,James E. Crowe +13 more
TL;DR: It is suggested that thermodynamic stabilization of the long HCDR3 in its active conformation is responsible for the increased potency of PG9_N100(F)Y, and strategies aimed at stabilizing this region in other HIV antibodies could become an important approach to in silico optimization of antibodies.
Journal ArticleDOI
Inactivated whole SIV vaccine in macaques: evaluation of protective efficacy against challenge with cell-free virus or infected cells.
Philip R. Johnson,Philip R. Johnson,David C. Montefiori,Simon Goldstein,Tiffany E. Hamm,Tiffany E. Hamm,Jiying Zhou,Svetlana Kitov,Nancy L. Haigwood,Lynda Misher,William T. London,John L. Gerin,Anthony C. Allison,Robert H. Purcell,Robert M. Chanock,Vanessa M. Hirsch +15 more