David C. Montefiori

TL;DR: A significant correlation of vaccine-induced sIgA titers in rectal secretions with delayed acquisition is shown for the first time, and further investigation of the characteristics and properties of the sIGA should elucidate the mechanism leading to this protective effect.

TL;DR: It is reported that fusion of Env and the complement component, C3d, in a DNA vaccine, enhances the titers of antibody to Env, and accelerated both the onset and the avidity maturation of the raised antibody.

TL;DR: Evaluating the ability of plasmid-based cytokines to serve as vaccine adjuvants in rhesus macaques demonstrated significantly elevated cell-mediated and humoral immune responses resulting in an improved clinical outcome following virus challenge compared to macaques receiving SIVgag pDNA alone.

TL;DR: While original V2 2F5 insertion mutant failed to elicit anti-2F5 peptide responses in mice, studies with 14 additional V2 insertion mutants revealed several insertion sites at which the epitope was able to induce epitope-specific antibody responses, suggesting that the configuration of 2F 5 epitope plays a critical role in inducing neutralizing antibody responses.

TL;DR: It is suggested that plasma-derived IgG antibodies mediate the majority of the low-level HIV neutralization and ADCC activity in breast milk.