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David C. Montefiori
Researcher at Duke University
Publications - 995
Citations - 79717
David C. Montefiori is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 129, co-authored 920 publications receiving 70049 citations. Previous affiliations of David C. Montefiori include Emory University & University of California, Davis.
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Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model.
C. Jane Batten,Robert De Rose,Kim Wilson,Michael B. Agy,Socheata Chea,Ivan Stratov,David C. Montefiori,Stephen J. Kent +7 more
TL;DR: The virologic and immunologic characteristics of HIV-1, SIV, and SHIV infection of naive pigtail macaques are compared across a series of preclinical HIV vaccine studies to evaluate potential AIDS vaccines in pigtails.
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A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
David R. Martinez,Alexandra Schäfer,Sophie M. C. Gobeil,Dapeng Li,Gabriela De la Cruz,Robert Parks,Xiaozhi Lu,Maggie Barr,Victoria Stalls,Katarzyna Janowska,Esther Beaudoin,Kartik Manne,Katayoun Mansouri,Robert J. Edwards,Kenneth D. Cronin,Boyd Yount,Kara Anasti,Stephanie A. Montgomery,Juanjie Tang,Hana Golding,Shaunna Shen,Tongqing Zhou,Peter D. Kwong,Barney S. Graham,John R. Mascola,David C. Montefiori,S. Munir Alam,Gregory D. Sempowski,Surender Khurana,Kevin Wiehe,Kevin O. Saunders,Priyamvada Acharya,Barton F. Haynes,Ralph S. Baric +33 more
TL;DR: In this paper, the mortality associated with sarbecovirus in severe acute respiratory syndrome coronavirus (SARS-CoV) and two variants of concern, including SARS CoV-2 variants, was investigated.
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Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting
Joan F. L. Richmond,Farah Mustafa,Shan Lu,Joseph C. Santoro,Jiayu Weng,Maryellen O'connell,Eva Maria Fenyö,Julia L. Hurwitz,David C. Montefiori,Harriet L. Robinson +9 more
TL;DR: The results highlight the low immunogenic potential of the HIV-1 Env and demonstrate that different Envs have different potentials to raise low titer neutralizing antibody.
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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses
M. Anthony Moody,Feng Gao,Thaddeus C. Gurley,Joshua D. Amos,Amit Kumar,Bhavna Hora,Dawn J. Marshall,John F. Whitesides,Shi-Mao Xia,Robert Parks,Krissey E. Lloyd,Kwan-Ki Hwang,Xiaozhi Lu,Mattia Bonsignori,Andrés Finzi,Nathan Vandergrift,S. Munir Alam,Guido Ferrari,Xiaoying Shen,Georgia D. Tomaras,Gift Kamanga,Myron S. Cohen,Noel E. Sam,Saidi Kapiga,Elin S. Gray,Nancy Tumba,Lynn Morris,Susan Zolla-Pazner,Susan Zolla-Pazner,Miroslaw K. Gorny,John R. Mascola,Beatrice H. Hahn,George M. Shaw,Joseph Sodroski,Hua-Xin Liao,David C. Montefiori,Peter T. Hraber,Bette T. Korber,Barton F. Haynes +38 more
TL;DR: A role for V3 and CD4bs antibodies in constraining the native envelope trimer in vivo to aneutralization-resistant phenotype is demonstrated, explaining why HIV-1 transmission generally occurs by tier 2 neutralization- resistant viruses.
Journal ArticleDOI
Origin and Evolution of HIV-1 in Breast Milk Determined by Single-Genome Amplification and Sequencing
Jesus F. Salazar-Gonzalez,Maria G. Salazar,Gerald H. Learn,Genevieve G. Fouda,Helen H. Kang,Tatenda Mahlokozera,Andrew B. Wilks,Rachel V. Lovingood,Andrea Stacey,Linda Kalilani,Steve Meshnick,Persephone Borrow,David C. Montefiori,Thomas N. Denny,Norman L. Letvin,George M. Shaw,Beatrice H. Hahn,Sallie R. Permar +17 more
TL;DR: The limited compartmentalization and the clonal amplification of evolving, functional viruses in milk indicate continual seeding of the mammary gland by blood virus variants, followed by transient local replication of these variants in the breast milk compartment.