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David Cartwright
Researcher at University of Birmingham
Publications - 9
Citations - 332
David Cartwright is an academic researcher from University of Birmingham. The author has contributed to research in topics: NAD+ kinase & Nicotinamide riboside. The author has an hindex of 4, co-authored 8 publications receiving 143 citations. Previous affiliations of David Cartwright include HealthPartners.
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Journal ArticleDOI
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Yasir S Elhassan,Yasir S Elhassan,Katarina Kluckova,Rachel Fletcher,Mark S. Schmidt,Antje Garten,Craig L. Doig,David Cartwright,Lucy Oakey,Claire V. Burley,Ned Jenkinson,Martin Wilson,Samuel J. E. Lucas,Ildem Akerman,Alex P. Seabright,Yu-Chiang Lai,Daniel A. Tennant,Peter Nightingale,Gareth A. Wallis,Konstantinos N. Manolopoulos,Konstantinos N. Manolopoulos,Charles Brenner,Andrew Philp,Andrew Philp,Andrew Philp,Gareth G. Lavery,Gareth G. Lavery +26 more
TL;DR: The data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR, and reveal NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics.
Journal ArticleDOI
Effectiveness of Bariatric Surgery vs Community Weight Management Intervention for the Treatment of Idiopathic Intracranial Hypertension: A Randomized Clinical Trial
Susan P Mollan,James L Mitchell,James L Mitchell,Ryan S Ottridge,Magda Aguiar,Andreas Yiangou,Andreas Yiangou,Andreas Yiangou,Zerin Alimajstorovic,Zerin Alimajstorovic,David Cartwright,David Cartwright,Olivia Grech,Olivia Grech,Gareth G. Lavery,Gareth G. Lavery,Connar Westgate,Vivek Vijay,Vivek Vijay,William J Scotton,Ben R. Wakerley,Tim Matthews,Alec M. Ansons,Simon J. Hickman,James D Benzimra,Caroline Rick,Rishi Singhal,Rishi Singhal,Abd A. Tahrani,Abd A. Tahrani,Abd A. Tahrani,Kristian Brock,Emma Frew,Alexandra J Sinclair,Alexandra J Sinclair,Alexandra J Sinclair +35 more
TL;DR: In this article, a 5-year randomized clinical trial (Idiopathic Intracranial Hypertension Weight Trial) enrolled women with active IIH and a body mass index (calculated as weight in kilograms divided by height in meters squared) of 35 or higher at 5 National Health Service hospitals in the UK between March 1, 2014 and May 25, 2017.
Journal ArticleDOI
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion
Lucy Oakey,Rachel Fletcher,Yasir S Elhassan,David Cartwright,Craig L. Doig,Antje Garten,Alpesh Thakker,Oliver D. K. Maddocks,Tong Zhang,Daniel A. Tennant,Christian Ludwig,Gareth G. Lavery +11 more
TL;DR: The need to consider carbon metabolism and clearance pathways when investigating NAD + precursor usage in models of skeletal muscle physiology is highlighted, and the functional relevance of increased aspartate levels after NAD + depletion remains unclear.
Posted ContentDOI
Autophagy promotes cell survival by maintaining NAD(H) levels
Lucia Sedlackova,Tetsushi Kataura,Elena Seranova,Congxin Sun,Elsje G. Otten,Malkiel A. Cohen,Miruna Chipara,Adina Maria Palhegyi,David Shapira,Filippo Scialò,Rhoda Stefanatos,Kei-Ichi Ishikawa,Niall S. Kenneth,Tong Zhang,Prashanta Kumar Panda,Malgorzata Zatyka,Luiz Felipe Souza E Silva,Jorge Torresi,Kevin J. Kauffman,Shupei Zhang,Dorothea Maetzel,Thiago Varga,Carl Ward,David Cartwright,Gareth G. Lavery,Gaurav Sahay,Yosef Buganim,Daniel G. Anderson,Animesh Acharjee,Charles C. Bascom,Ryan Tasseff,Robert J. Isfort,John Erich Oblong,Joerg Gsponer,Satomi Miwa,Michael Lazarou,Manolis Papamichos-Chronakis,Haoyi Wang,Masaya Imoto,Shinji Saiki,Oliver D. K. Maddocks,Alberto Sanz,Tatiana R. Rosenstock,Rudolf Jaenisch,Viktor I. Korolchuk,Sovan Sarkar +45 more
TL;DR: An evolutionarily conserved role of autophagy from yeast to humans in the preservation of nicotinamide adenine dinucleotide (NAD+/NADH) levels, which are critical for cellular survival are identified.
Journal ArticleDOI
Nicotinamide riboside has minimal impact on energy metabolism in mouse models of mild obesity.
David Cartwright,Lucy Oakey,Rachel Fletcher,Craig L. Doig,Craig L. Doig,Silke Heising,Dean Larner,Daniela Nasteska,Caitlin E Berry,Sam R Heaselgrave,Christian Ludwig,David J. Hodson,Gareth G. Lavery,Antje Garten,Antje Garten +14 more
TL;DR: In this paper, the effects of NR supplementation on whole-body energy metabolism and mitochondrial function in mild obese C57BL/6N and C57bl/6J mice, two commonly used strains to investigate metabolism.