G
Gareth G. Lavery
Researcher at University of Birmingham
Publications - 137
Citations - 6128
Gareth G. Lavery is an academic researcher from University of Birmingham. The author has contributed to research in topics: Glucocorticoid & Skeletal muscle. The author has an hindex of 35, co-authored 114 publications receiving 4861 citations. Previous affiliations of Gareth G. Lavery include University of Giessen & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Jeremy W. Tomlinson,Elizabeth A. Walker,Iwona J. Bujalska,Nicole Draper,Gareth G. Lavery,Mark S. Cooper,Martin Hewison,Paul M. Stewart +7 more
TL;DR: It is speculated that hexose-6-phosphate dehydrogenase activity and therefore reduced nicotinamide-adenine dinucleotide phosphate supply may be crucial in determining the directionality of 11beta-HSD1 activity.
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Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)
Nils Krone,Beverly A. Hughes,Gareth G. Lavery,Paul M. Stewart,Wiebke Arlt,Cedric H. L. Shackleton +5 more
TL;DR: This work has led to develop a simplified graphical representation of quantitative urinary steroid hormone profiles and diagnostic ratios, which remains the most powerful discovery tool for defining steroid disorder metabolomes.
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Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
Nicole Draper,Elizabeth A. Walker,Iwona J. Bujalska,Jeremy W. Tomlinson,Susan M Chalder,Wiebke Arlt,Gareth G. Lavery,Oliver Bedendo,David W. Ray,Ian Laing,Ewa M. Malunowicz,Perrin C. White,Martin Hewison,Philip J. Mason,John M. C. Connell,Cedric H.L. Shackleton,Paul M. Stewart +16 more
TL;DR: A defect in the gene HSD11B1 encoding 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a primary regulator of tissue-specific glucocorticoid bioavailability, is suggested and H6PDH is established as a potential factor in the pathogenesis of PCOS.
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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Yasir S Elhassan,Yasir S Elhassan,Katarina Kluckova,Rachel Fletcher,Mark S. Schmidt,Antje Garten,Craig L. Doig,David Cartwright,Lucy Oakey,Claire V. Burley,Ned Jenkinson,Martin Wilson,Samuel J. E. Lucas,Ildem Akerman,Alex P. Seabright,Yu-Chiang Lai,Daniel A. Tennant,Peter Nightingale,Gareth A. Wallis,Konstantinos N. Manolopoulos,Konstantinos N. Manolopoulos,Charles Brenner,Andrew Philp,Andrew Philp,Andrew Philp,Gareth G. Lavery,Gareth G. Lavery +26 more
TL;DR: The data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR, and reveal NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics.
Journal ArticleDOI
Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
Gareth G. Lavery,Gareth G. Lavery,Elizabeth A. Walker,Nicole Draper,Nicole Draper,Pancharatnam Jeyasuria,Josep Marcos,Cedric H.L. Shackleton,Keith L. Parker,Perrin C. White,Paul M. Stewart +10 more
TL;DR: The studies define the critical requirement of hexose-6-phosphate dehydrogenase for 11β-HSD1 oxoreductase activity and add a new dimension to the investigation of 11 β- HSD1 as a therapeutic target in patients with the metabolic syndrome.